| Reaction Details |
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 | Report a problem with these data |
| Target | DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
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| Ligand | BDBM518738 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-Fret Assay |
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| IC50 | 206±n/a nM |
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| Citation |  Min, J; Scott, DC; Bhasin, D; Schulman, BA; Singh, B; Hammill, JT; Guy, RK Methods and compositions of inhibiting DCN1-UBC12 interaction US Patent US11116757 Publication Date 9/14/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
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| Name: | DCN1-like protein 1/NEDD8-conjugating enzyme Ubc12 |
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| Synonyms: | DCN1-UBC12 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | NEDD8-conjugating enzyme Ubc12 |
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| Synonyms: | 2.3.2.- | NEDD8 carrier protein | NEDD8-conjugating enzyme Ubc12 | UBC12 | UBC12_HUMAN | UBE2M | Ubiquitin-conjugating enzyme E2 M |
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| Type: | PROTEIN |
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| Mol. Mass.: | 20901.74 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118032 |
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| Residue: | 183 |
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| Sequence: | MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNF
KLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWK
PVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFER
CLK
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| Component 2 |
| Name: | DCN1-like protein 1 |
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| Synonyms: | DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30118.96 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117443 |
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| Residue: | 259 |
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| Sequence: | MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSL
DRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQ
EFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIA
YWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLI
DDFVEFARPQIAGTKSTTV
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| BDBM518738 |
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| n/a |
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| Name | BDBM518738 |
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| Synonyms: | US11116757, No. A36 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N4O3 |
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| Mol. Mass. | 438.5625 |
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| SMILES | CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(C)c(c1)[N+]([O-])=O |
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| Structure | 
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