| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor [Y537S] |
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| Ligand | BDBM443434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ERalpha (Wild Type), ERalpha (Y537ERalpha (Wild Type), ERalph (Y537S Mutant) and ERbeta Competition Binding Assay |
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| Ki | 7.92±n/a nM |
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| Citation |  Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Selective estrogen receptor degraders US Patent US11117902 Publication Date 9/14/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor [Y537S] |
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| Name: | Estrogen receptor [Y537S] |
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| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor (Y537S) | Estrogen receptor alpha Y537S | NR3A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66154.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372[Y537S] |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM443434 |
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| n/a |
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| Name | BDBM443434 |
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| Synonyms: | US10654866, Example 2B | US11117902, Example 2A | US11634426, Example 2B |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24F4N2O3 |
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| Mol. Mass. | 524.5061 |
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| SMILES | Oc1ccc2c3[C@@H](Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 |r| |
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| Structure | 
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