Ki Summary

Reaction Details

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Target

Glutamate receptor ionotropic, NMDA 2B

Ligand

BDBM521616

Substrate/Competitor

n/a

Meas. Tech.

Whole-Cell Patch Clamp of Mammalian Cells (Ionworks Barracuda (IWB))

EC50

166±n/a nM

Citation

Salituro, FG; Robichaud, AJ; Martinez Botella, G; Harrison, BL; Griffin, A Oxysterols and methods of use thereof US Patent US11149054 Publication Date 10/19/2021

More Info.:

Get all data from this article, Assay Method

Glutamate receptor ionotropic, NMDA 2B

Name:

Glutamate receptor ionotropic, NMDA 2B

Synonyms:

Type:

PROTEIN

Mol. Mass.:

166375.46

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1438829

Residue:

1484

Sequence:

MKPRAECCSPKFWLVLAVLAVSGSRARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFH
HLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTL
TPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQ
DFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYI
FEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAII
TTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHP
KLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYL
VTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSR
SNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSF
TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV
DQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLS
LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAI
LQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILR
LLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFS
DYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSASSIDGLYDCDNPPFTTQSRSISK
KPLDIGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKR
RKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTK
ENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHIKHGTGDKHGVVSGVPAPWEKN
LTNVEWEDRSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRCEACKKAGNLYDISEDNSL
QELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
SVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTAGHHHHNNPGGGYMLSKSLYPD
RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKARPDFRALVTNKPVVSALHGAVPA
RFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV

BDBM521616

n/a

Name

BDBM521616

Synonyms:

US11149054, Compound 4585

Type

Small organic molecule

Emp. Form.

C31H51F3O3

Mol. Mass.

528.73

SMILES

CO[C@H]1CC[C@](O)(CC[C@@H](C)[C@H]2CC[C@H]3[C@@H]4CC[C@H]5C[C@@](O)(CC[C@]5(C)[C@H]4CC[C@]23C)C(F)(F)F)CC1 |r,wU:18.18,26.28,14.13,20.20,24.25,11.10,5.6,29.33,wD:15.15,20.34,9.9,5.5,2.1,(9.47,-.28,;7.99,-.68,;6.9,.41,;7.3,1.9,;6.21,2.99,;4.72,2.59,;4.72,4.13,;3.21,2.27,;2.18,3.41,;.68,3.09,;-.35,4.24,;.2,1.63,;1.11,.38,;.2,-.86,;-1.26,-.39,;-2.6,-1.16,;-2.6,-2.7,;-3.93,-3.47,;-5.27,-2.7,;-6.6,-3.47,;-7.93,-2.7,;-9.02,-3.79,;-7.93,-1.16,;-6.6,-.39,;-5.27,-1.16,;-5.27,.38,;-3.93,-.39,;-3.93,1.15,;-2.6,1.92,;-1.26,1.15,;-1.1,2.68,;-9.47,-2.7,;-10.24,-1.36,;-10.24,-4.03,;-11.01,-2.7,;4.32,1.1,;5.41,.01,)|

Structure