Ki Summary

Reaction Details

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Target

Glutamate receptor ionotropic, NMDA 2A

Ligand

BDBM521617

Substrate/Competitor

n/a

Meas. Tech.

Whole-Cell Patch Clamp of Mammalian Cells (Ionworks Barracuda (IWB))

EC50

53.4±n/a nM

Citation

Salituro, FG; Robichaud, AJ; Martinez Botella, G; Harrison, BL; Griffin, A Oxysterols and methods of use thereof US Patent US11149054 Publication Date 10/19/2021

More Info.:

Get all data from this article, Assay Method

Glutamate receptor ionotropic, NMDA 2A

Name:

Glutamate receptor ionotropic, NMDA 2A

Synonyms:

Type:

n/a

Mol. Mass.:

165293.76

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

1464

Sequence:

MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
TPRVLNSCSNRRVYKKMPSIESDV

BDBM521617

n/a

Name

BDBM521617

Synonyms:

US11149054, Compound 3886

Type

Small organic molecule

Emp. Form.

C31H51F3O2

Mol. Mass.

512.7306

SMILES

C[C@H](CC[C@@]1(O)CC[C@H](C)CC1)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@](O)(CC[C@]4(C)[C@H]3CC[C@]12C)C(F)(F)F |r,wU:19.20,27.30,15.15,21.22,25.27,12.12,4.3,30.35,wD:16.17,21.36,1.0,4.4,8.8,(.39,4.24,;1.42,3.09,;2.93,3.41,;3.96,2.27,;5.46,2.59,;5.46,4.13,;6.95,2.99,;8.04,1.9,;7.64,.41,;8.73,-.68,;6.15,.01,;5.06,1.1,;.94,1.63,;1.85,.38,;.94,-.86,;-.52,-.39,;-1.85,-1.16,;-1.85,-2.7,;-3.19,-3.47,;-4.52,-2.7,;-5.86,-3.47,;-7.19,-2.7,;-8.28,-3.79,;-7.19,-1.16,;-5.86,-.39,;-4.52,-1.16,;-4.52,.38,;-3.19,-.39,;-3.19,1.15,;-1.85,1.92,;-.52,1.15,;-.36,2.68,;-8.73,-2.7,;-9.5,-1.36,;-9.5,-4.03,;-10.27,-2.7,)|

Structure