| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B [168-495] |
|---|
| Ligand | BDBM522100 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Enzyme Inhibition Using a Biochemical Peptide Phosphorylation Assay- Caliper Assay |
|---|
| IC50 | 5300±n/a nM |
|---|
| Citation |  Arista, L; Chamoin, S; D''Alessandro, PL; Lindvall, M; Lizos, D; Stiefl, NJ; Teixeira-Fouchard, S; Ullrich, T; Weiler, S Pyridinone derivatives and their use as selective ALK-2 inhibitors US Patent US11160797 Publication Date 11/2/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bone morphogenetic protein receptor type-1B [168-495] |
|---|
| Name: | Bone morphogenetic protein receptor type-1B [168-495] |
|---|
| Synonyms: | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 37241.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00238[168-495] |
|---|
| Residue: | 328 |
|---|
| Sequence: | TYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEK
VAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSL
YDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCC
IADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLIL
WEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMG
KLMTECWAHNPASRLTALRVKKTLAKMS
|
|
|
|---|
| BDBM522100 |
|---|
| n/a |
|---|
| Name | BDBM522100 |
|---|
| Synonyms: | US11160797, Example 8 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23N3O2 |
|---|
| Mol. Mass. | 385.4583 |
|---|
| SMILES | CN1C(=O)Cc2cc(ccc12)-c1cncc(c1)-c1ccc(=O)n(c1)C1CCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
