| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 2 |
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| Ligand | BDBM525321 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 0.380±n/a nM |
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| Citation |  Shamloo, M; Jahangir, A; Yi, B; Evans, AK; Green, MJ Adrenergic receptor modulating compounds and methods of using the same US Patent US11173144 Publication Date 11/16/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-adrenergic receptor kinase 2 |
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| Name: | Beta-adrenergic receptor kinase 2 |
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| Synonyms: | ADRBK2 | ARBK2_HUMAN | BARK2 | GRK3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79721.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_615172 |
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| Residue: | 688 |
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| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
APKFLNKPRSGTVELPKPSLCHRNSNGL
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| BDBM525321 |
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| n/a |
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| Name | BDBM525321 |
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| Synonyms: | US11173144, Compound 55 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N3O5 |
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| Mol. Mass. | 401.4562 |
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| SMILES | COc1ccc(OCCNC[C@H](O)COc2cccc3[nH]nc(C)c23)cc1OC |r| |
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| Structure | 
|
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