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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Ligand | BDBM527816 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biochemical Assay | ||
| IC50 | 3.10±n/a nM | ||
| Citation |  Chin, G; Clarke, MO; Han, X; Hansen, T; Hu, YE; Koltun, D; McFadden, R; Mish, MR; Parkhill, EQ; Sperandio, D; Xu, L; Yang, H Imidazopyrimidine derivatives US Patent US11179397 Publication Date 11/23/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein phosphatase non-receptor type 11 | |||
| Name: | Tyrosine-protein phosphatase non-receptor type 11 | ||
| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) | ||
| Type: | Protein phosphatase | ||
| Mol. Mass.: | 68443.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q06124 | ||
| Residue: | 593 | ||
| Sequence: |
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| BDBM527816 | |||
| n/a | |||
| Name | BDBM527816 | ||
| Synonyms: | (2R,4R)-4-amino-8- (8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan-2- ol | US11179397, Example 33 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25Cl2N5O | ||
| Mol. Mass. | 446.373 | ||
| SMILES | Cc1nc(N2CCC3(C[C@@H](O)C[C@H]3N)CC2)n2ccnc2c1-c1cccc(Cl)c1Cl |r,wD:12.13,9.9,(-1.22,3.55,;-1.22,2.01,;.11,1.24,;.11,-.3,;1.45,-1.07,;1.45,-2.61,;2.78,-3.38,;4.12,-2.61,;4.28,-4.14,;5.78,-4.46,;6.41,-5.86,;6.55,-3.12,;5.52,-1.98,;5.84,-.47,;4.12,-1.07,;2.78,-.3,;-1.22,-1.07,;-1.54,-2.57,;-3.07,-2.73,;-3.7,-1.33,;-2.55,-.3,;-2.55,1.24,;-3.89,2.01,;-5.22,1.24,;-6.55,2.01,;-6.55,3.55,;-5.22,4.32,;-5.22,5.86,;-3.89,3.55,;-2.55,4.32,)| | ||
| Structure | 
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