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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase kinase 1 | ||
| Ligand | BDBM529862 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TBHPK1 IC50 Assay | ||
| IC50 | 0.030±n/a nM | ||
| Citation |  Balan, G; Bartlett, MJ; Chandrasekhar, J; Codelli, JA; Conway, JH; Cosman, JL; Kalla, RV; Kasun, ZA; Kim, M; Lee, SH; Lo, JR; Loyer-Drew, JA; Mitchell, SA; Perry, TD; Phillips, GB; Salvo, PJ; Swaminathan, S; Van Veldhuizen, JJ; Yeung, SC; Zablocki, J Substituted 6-azabenzimidazole compounds US Patent US11203591 Publication Date 12/21/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase kinase 1 | |||
| Name: | Mitogen-activated protein kinase kinase kinase kinase 1 | ||
| Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 91316.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_586597 | ||
| Residue: | 833 | ||
| Sequence: |
| ||
| BDBM529862 | |||
| n/a | |||
| Name | BDBM529862 | ||
| Synonyms: | US11203591, Example 268 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C39H45F4N7O2 | ||
| Mol. Mass. | 719.8139 | ||
| SMILES | CC(C)n1cnc2cc(nc(Nc3cc(C(=O)NCC(F)F)c(C)c(F)c3F)c12)-c1ccc2c(c1)N(C1CC(C)(C1)N1CCCCC1)C(=O)C2(C)C |(13.94,7.78,;12.91,6.63,;13.39,5.17,;11.4,6.95,;10.78,8.36,;9.25,8.2,;8.93,6.69,;7.59,5.92,;7.59,4.38,;8.93,3.61,;10.26,4.38,;11.59,3.61,;11.59,2.07,;12.93,1.3,;12.93,-.24,;14.26,-1.01,;15.59,-.24,;14.26,-2.55,;15.59,-3.32,;15.59,-4.86,;16.93,-5.63,;14.26,-5.63,;11.59,-1.01,;11.59,-2.55,;10.26,-.24,;8.93,-1.01,;10.26,1.3,;8.93,2.07,;10.26,5.92,;6.26,3.61,;6.26,2.07,;4.92,1.3,;3.59,2.07,;3.59,3.61,;4.92,4.38,;2.13,4.09,;1.65,5.55,;.28,6.25,;.98,7.62,;1.34,9.12,;2.35,6.93,;-.19,8.62,;-1.65,8.11,;-2.82,9.11,;-2.54,10.63,;-1.08,11.14,;.09,10.14,;1.22,2.84,;-.32,2.84,;2.13,1.6,;2.43,.09,;.99,.55,)| | ||
| Structure | 
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