Reaction Details |
| Report a problem with these data |
Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Ligand | BDBM530430 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | DHODH enzymatic assay |
---|
IC50 | 0.18±n/a nM |
---|
Citation | Lindsey, D; Scott, K; Zhuming, Z DIHYDROOROTATE DEHYDROGENASE INHIBITORS WIPOWO2022070068 Publication Date 4/7/2022 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
BDBM530430 |
---|
n/a |
---|
Name | BDBM530430 |
Synonyms: | 6-(6-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopropyl-2-(o-tolyl)isoquinolin- 1(2H)-one. | WO2022070068, Example 2 |
Type | Small organic molecule |
Emp. Form. | C25H24FN3O |
Mol. Mass. | 401.476 |
SMILES | CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1ccc(C)c(N)n1 |
Structure |
|