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Compile Data Set for Download or QSAR

Found 43 hits with Last Name = 'lindsey' and Initial = 'd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530430
PNG
(6-(6-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopro...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1ccc(C)c(N)n1
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n/an/a 0.180n/an/an/an/an/an/a


TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530461
PNG
(N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro-4-(...)
Show SMILES C[C@@H](O)c1nn(cc1C)-c1cc(O[C@@H](C)C(F)(F)F)c(cc1F)C(=O)Nc1c(C)n[nH]c1Cl |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BV7KSB
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530462
PNG
(N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro-4-(...)
Show SMILES C[C@H](O)c1nn(cc1C)-c1cc(O[C@@H](C)C(F)(F)F)c(cc1F)C(=O)Nc1c(C)n[nH]c1Cl |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BV7KSB
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530459
PNG
(N-(2-Chloro-6-fluorophenyl)-5-fluoro-4-(3-((S*)-1-...)
Show SMILES C[C@H](O)c1nn(cc1C)-c1cc(O[C@@H](C)C(F)(F)F)c(cc1F)C(=O)Nc1c(F)cccc1Cl |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BV7KSB
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530463
PNG
((S)-N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro...)
Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)n[nH]c1Cl)-n1cc(C)c(n1)C(C)(C)O)C(F)(F)F |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BV7KSB
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530432
PNG
(7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530442
PNG
(7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Show SMILES CC(C)c1nn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530458
PNG
(N-(2-Chloro-6-fluorophenyl)-5-fluoro-4-(3-((R*)-1-...)
Show SMILES C[C@@H](O)c1nn(cc1C)-c1cc(O[C@@H](C)C(F)(F)F)c(cc1F)C(=O)Nc1c(F)cccc1Cl |r|
PDB
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n/an/a 0.480n/an/an/an/an/an/a


TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BV7KSB
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530441
PNG
((S*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc([C@H](C)O)n(C)n1 |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530460
PNG
((S)-N-(2-Chloro-6-fluorophenyl)-5-fluoro-4-(3-(2-h...)
Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1cc(C)c(n1)C(C)(C)O)C(F)(F)F |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2BV7KSB
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530439
PNG
((R*)-7-Fluoro-6-(2-(1-hydroxyethyl)-1-methyl-1H-im...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)[C@@H](C)O |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530444
PNG
(2-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-6-(...)
Show SMILES CC(C)c1cn(-c2c(C)n[nH]c2Cl)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O |(-3.83,4.14,;-2.5,3.37,;-1.17,4.14,;-2.5,1.83,;-3.83,1.06,;-3.83,-.48,;-5.17,-1.25,;-5.33,-2.78,;-4.18,-3.81,;-6.83,-3.1,;-7.6,-1.77,;-6.57,-.62,;-6.89,.88,;-2.5,-1.25,;-2.5,-2.79,;-1.17,-.48,;.17,-1.25,;1.5,-.48,;2.83,-1.25,;1.5,1.06,;.17,1.83,;-1.17,1.06,;2.83,1.83,;4.17,1.06,;5.31,2.09,;6.82,1.77,;4.69,3.5,;3.16,3.34,;5.46,4.83,;7,4.83,;3.92,4.83,;4.69,6.17,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530432
PNG
(7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O
PDB
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530435
PNG
(7-Fluoro-6-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc(n(C)n1)C(C)(C)O
PDB
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n/an/a 0.570n/an/an/an/an/an/a


TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530435
PNG
(7-Fluoro-6-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc(n(C)n1)C(C)(C)O
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530445
PNG
(2-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-6-(...)
Show SMILES CC(C)c1cn(-c2c(C)n[nH]c2Cl)c(=O)c2cc(F)c(cc12)-c1nc(n(C)n1)C(C)(C)O |(-3.83,4.14,;-2.5,3.37,;-1.17,4.14,;-2.5,1.83,;-3.83,1.06,;-3.83,-.48,;-5.17,-1.25,;-5.33,-2.78,;-4.18,-3.81,;-6.83,-3.1,;-7.6,-1.77,;-6.57,-.62,;-6.89,.88,;-2.5,-1.25,;-2.5,-2.79,;-1.17,-.48,;.17,-1.25,;1.5,-.48,;2.83,-1.25,;1.5,1.06,;.17,1.83,;-1.17,1.06,;2.83,1.83,;3.16,3.34,;4.69,3.5,;5.31,2.09,;6.82,1.77,;4.17,1.06,;5.46,4.83,;7,4.83,;3.92,4.83,;4.69,6.17,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530438
PNG
((S*)-7-Fluoro-6-(2-(1-hydroxyethyl)-1-methyl-1H-im...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)[C@H](C)O |r|
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n/an/a 0.730n/an/an/an/an/an/a


TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530433
PNG
(Racemic 7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc(C(C)O)n(C)n1
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530441
PNG
((S*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc([C@H](C)O)n(C)n1 |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530436
PNG
(7-Fluoro-6-(2-(hydroxymethyl)-1-methyl-1H-imidazol...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(CO)n1
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530453
PNG
(7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Show SMILES COc1cc(c(C)cn1)-n1cc(C(C)C)c2cc(-c3cn(C)c(n3)C(C)(C)O)c(F)cc2c1=O
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530454
PNG
(7-Fluoro-6-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...)
Show SMILES COc1cc(c(C)cn1)-n1cc(C(C)C)c2cc(-c3nc(n(C)n3)C(C)(C)O)c(F)cc2c1=O
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530465
PNG
(8-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...)
Show SMILES CCn1c(CO)nn(-c2cc3c(cc(-c4ccccc4C)c(=O)n3cc2F)C(C)C)c1=O
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530455
PNG
(2-(3-Chloro-6-methylpyridin-2-yl)-7-fluoro-6-(2-(2...)
Show SMILES CC(C)c1cn(-c2nc(C)ccc2Cl)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O
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WIPO WO2022070068
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530440
PNG
((R*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc([C@@H](C)O)n(C)n1 |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530434
PNG
(6-(5-Acetyl-1-methyl-1H-1,2,4-triazol-3-yl)-7-fluo...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc(C(C)=O)n(C)n1
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530446
PNG
(2-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-6-(2-(2...)
Show SMILES CC(C)c1cn(-c2c(C)ccnc2Cl)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O |(-3.83,4.14,;-2.5,3.37,;-1.17,4.14,;-2.5,1.83,;-3.83,1.06,;-3.83,-.48,;-5.17,-1.25,;-5.17,-2.79,;-3.83,-3.56,;-6.5,-3.56,;-7.83,-2.79,;-7.83,-1.25,;-6.5,-.48,;-6.5,1.06,;-2.5,-1.25,;-2.5,-2.79,;-1.17,-.48,;.17,-1.25,;1.5,-.48,;2.83,-1.25,;1.5,1.06,;.17,1.83,;-1.17,1.06,;2.83,1.83,;4.17,1.06,;5.31,2.09,;6.82,1.77,;4.69,3.5,;3.16,3.34,;5.46,4.83,;7,4.83,;3.92,4.83,;4.69,6.17,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530440
PNG
((R*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc([C@@H](C)O)n(C)n1 |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530467
PNG
(3-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-8-(...)
Show SMILES CC(C)c1cc(-c2c(C)n[nH]c2Cl)c(=O)n2cc(F)c(cc12)-c1nc(n(C)n1)C(C)(C)O |(-3.5,2.52,;-2.17,1.75,;-.83,2.52,;-2.17,.21,;-3.5,-.56,;-3.5,-2.1,;-4.83,-2.87,;-6.24,-2.25,;-6.56,-.74,;-7.27,-3.39,;-6.5,-4.73,;-5,-4.4,;-3.85,-5.44,;-2.17,-2.87,;-2.17,-4.41,;-.83,-2.1,;.5,-2.87,;1.83,-2.1,;3.17,-2.87,;1.83,-.56,;.5,.21,;-.83,-.56,;3.17,.21,;3.33,1.74,;4.84,2.06,;5.61,.72,;7.14,.56,;4.58,-.42,;5.46,3.47,;6.99,3.63,;6.37,2.22,;4.56,4.71,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530464
PNG
(7-Fluoro-8-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Show SMILES CC(C)c1cc(-c2ccccc2C)c(=O)n2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O
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n/an/a 2.11n/an/an/an/an/an/a


TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530447
PNG
(2-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-6-(5-(2...)
Show SMILES CC(C)c1cn(-c2c(C)ccnc2Cl)c(=O)c2cc(F)c(cc12)-c1nc(n(C)n1)C(C)(C)O |(-3.83,4.14,;-2.5,3.37,;-1.17,4.14,;-2.5,1.83,;-3.83,1.06,;-3.83,-.48,;-5.17,-1.25,;-5.17,-2.79,;-3.83,-3.56,;-6.5,-3.56,;-7.83,-2.79,;-7.83,-1.25,;-6.5,-.48,;-6.5,1.06,;-2.5,-1.25,;-2.5,-2.79,;-1.17,-.48,;.17,-1.25,;1.5,-.48,;2.83,-1.25,;1.5,1.06,;.17,1.83,;-1.17,1.06,;2.83,1.83,;3.16,3.34,;4.69,3.5,;5.31,2.09,;6.82,1.77,;4.17,1.06,;5.46,4.83,;7,4.83,;3.92,4.83,;4.69,6.17,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530469
PNG
(7-Fluoro-8-(5-(2-hydroxypropan-2-yl)-1-methyl-1H-1...)
Show SMILES CC(C)c1cc(-c2c(C)n[nH]c2C(F)(F)F)c(=O)n2cc(F)c(cc12)-c1nc(n(C)n1)C(C)(C)O |(-3.5,2.52,;-2.17,1.75,;-.83,2.52,;-2.17,.21,;-3.5,-.56,;-3.5,-2.1,;-4.83,-2.87,;-6.24,-2.25,;-6.56,-.74,;-7.27,-3.39,;-6.5,-4.73,;-5,-4.4,;-3.85,-5.44,;-4.17,-6.94,;-2.39,-4.96,;-2.71,-6.47,;-2.17,-2.87,;-2.17,-4.41,;-.83,-2.1,;.5,-2.87,;1.83,-2.1,;3.17,-2.87,;1.83,-.56,;.5,.21,;-.83,-.56,;3.17,.21,;3.33,1.74,;4.84,2.06,;5.61,.72,;7.14,.56,;4.58,-.42,;5.46,3.47,;6.99,3.63,;6.37,2.22,;4.56,4.71,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530429
PNG
(6-(5-Cyclopropylpyrazin-2-yl)-7-fluoro-4-isopropyl...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cnc(cn1)C1CC1
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530443
PNG
((R*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,...)
Show SMILES CC(C)c1nn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)[C@@H](C)O |r|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530437
PNG
(7-Fluoro-6-(5-(hydroxymethyl)-1-methyl-1H-1,2,4-tr...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc(CO)n(C)n1
PDB
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530466
PNG
(3-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-7-fluoro-8-(...)
Show SMILES CC(C)c1cc(-c2c(C)n[nH]c2Cl)c(=O)n2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O |(-3.5,2.52,;-2.17,1.75,;-.83,2.52,;-2.17,.21,;-3.5,-.56,;-3.5,-2.1,;-4.83,-2.87,;-6.24,-2.25,;-6.56,-.74,;-7.27,-3.39,;-6.5,-4.73,;-5,-4.4,;-3.85,-5.44,;-2.17,-2.87,;-2.17,-4.41,;-.83,-2.1,;.5,-2.87,;1.83,-2.1,;3.17,-2.87,;1.83,-.56,;.5,.21,;-.83,-.56,;3.17,.21,;4.58,-.42,;5.61,.72,;7.14,.56,;4.84,2.06,;3.33,1.74,;5.46,3.47,;6.99,3.63,;6.37,2.22,;4.56,4.71,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530431
PNG
(6-(4-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopro...)
Show SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cc(N)c(C)cn1
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530468
PNG
(7-Fluoro-8-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Show SMILES CC(C)c1cc(-c2c(C)n[nH]c2C(F)(F)F)c(=O)n2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O |(-3.5,2.52,;-2.17,1.75,;-.83,2.52,;-2.17,.21,;-3.5,-.56,;-3.5,-2.1,;-4.83,-2.87,;-6.24,-2.25,;-6.56,-.74,;-7.27,-3.39,;-6.5,-4.73,;-5,-4.4,;-3.85,-5.44,;-4.17,-6.94,;-2.39,-4.96,;-2.71,-6.47,;-2.17,-2.87,;-2.17,-4.41,;-.83,-2.1,;.5,-2.87,;1.83,-2.1,;3.17,-2.87,;1.83,-.56,;.5,.21,;-.83,-.56,;3.17,.21,;4.58,-.42,;5.61,.72,;7.14,.56,;4.84,2.06,;3.33,1.74,;5.46,3.47,;6.99,3.63,;6.37,2.22,;4.56,4.71,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530452
PNG
(6-(5-Acetyl-1-ethyl-1H-1,2,4-triazol-3-yl)-7-fluor...)
Show SMILES CCn1nc(nc1C(C)=O)-c1cc2c(cn(-c3ccccc3C)c(=O)c2cc1F)C(C)C
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530470
PNG
(3-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-8-(2-(2...)
Show SMILES CC(C)c1cc(-c2c(C)ccnc2Cl)c(=O)n2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O |(-3.5,2.52,;-2.17,1.75,;-.83,2.52,;-2.17,.21,;-3.5,-.56,;-3.5,-2.1,;-4.83,-2.87,;-6.17,-2.1,;-6.17,-.56,;-7.5,-2.87,;-7.5,-4.41,;-6.17,-5.18,;-4.83,-4.41,;-3.5,-5.18,;-2.17,-2.87,;-2.17,-4.41,;-.83,-2.1,;.5,-2.87,;1.83,-2.1,;3.17,-2.87,;1.83,-.56,;.5,.21,;-.83,-.56,;3.17,.21,;4.58,-.42,;5.61,.72,;7.14,.56,;4.84,2.06,;3.33,1.74,;5.46,3.47,;6.99,3.63,;6.37,2.22,;4.56,4.71,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530471
PNG
(3-(2-Chloro-4-methylpyridin-3-yl)-7-fluoro-8-(5-(2...)
Show SMILES CC(C)c1cc(-c2c(C)ccnc2Cl)c(=O)n2cc(F)c(cc12)-c1nc(n(C)n1)C(C)(C)O |(-3.5,2.52,;-2.17,1.75,;-.83,2.52,;-2.17,.21,;-3.5,-.56,;-3.5,-2.1,;-4.83,-2.87,;-6.17,-2.1,;-6.17,-.56,;-7.5,-2.87,;-7.5,-4.41,;-6.17,-5.18,;-4.83,-4.41,;-3.5,-5.18,;-2.17,-2.87,;-2.17,-4.41,;-.83,-2.1,;.5,-2.87,;1.83,-2.1,;3.17,-2.87,;1.83,-.56,;.5,.21,;-.83,-.56,;3.17,.21,;3.33,1.74,;4.84,2.06,;5.61,.72,;7.14,.56,;4.58,-.42,;5.46,3.47,;6.99,3.63,;6.37,2.22,;4.56,4.71,)|
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2736V3S
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530456
PNG
(6-(1-Ethyl-5-(1-hydroxyethyl)-1H-1,2,4-triazol-3-y...)
Show SMILES CCn1nc(nc1C(C)O)-c1cc2c(cn(-c3ccccc3C)c(=O)c2cc1F)C(C)C
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TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))
BDBM530448
PNG
(6-(1-Ethyl-5-(2-hydroxypropan-2-yl)-1H-1,2,4-triaz...)
Show SMILES CCn1nc(nc1C(C)(C)O)-c1cc2c(cn(-c3ccccc3C)c(=O)c2cc1F)C(C)C
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
WIPO WO2022070068
n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2GM8BGM
More data for this
Ligand-Target Pair