| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM530432 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DHODH enzymatic assay |
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| IC50 | 0.38±n/a nM |
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| Citation |  Lindsey, D; Scott, K; Zhuming, Z DIHYDROOROTATE DEHYDROGENASE INHIBITORS WIPOWO2022070068 Publication Date 4/7/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM530432 |
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| n/a |
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| Name | BDBM530432 |
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| Synonyms: | 7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-imidazol-4-yl)-4-isopropyl-2- (o-tolyl)isoquinolin-1(2H)-one. | WO2022070068, Example 23 | WO2022070068, Example 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28FN3O2 |
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| Mol. Mass. | 433.5178 |
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| SMILES | CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O |
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| Structure | 
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