| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM530463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DHODH enzymatic assay |
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| IC50 | 0.38±n/a nM |
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| Citation |  Lindsey, D; Scott, K DIHYDROOROTATE DEHYDROGENASE INHIBITORS WIPOWO2022070069 Publication Date 4/7/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM530463 |
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| n/a |
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| Name | BDBM530463 |
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| Synonyms: | (S)-N-(5-Chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro-4-(3-(2-hydroxypropan-2-yl)-4-methyl-1H-pyrazol-1-yl)-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide | WO2022070069, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22ClF4N5O3 |
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| Mol. Mass. | 503.878 |
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| SMILES | C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)n[nH]c1Cl)-n1cc(C)c(n1)C(C)(C)O)C(F)(F)F |r| |
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| Structure | 
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