| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Platelet-derived growth factor receptor beta |
|---|
| Ligand | BDBM531233 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDGFRbeta Enzyme Inhibition |
|---|
| Ki | 5.00±n/a nM |
|---|
| Citation |  Walters, I; Birch, L; Collingwood, SP; Stevenson, CS Indole derivatives and their use as protein kinase inhibitors US Patent US11208381 Publication Date 12/28/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Platelet-derived growth factor receptor beta |
|---|
| Name: | Platelet-derived growth factor receptor beta |
|---|
| Synonyms: | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF Receptor Substrate | PDGF-R-beta | PDGFR | PDGFR substrate | PDGFR-1 | PDGFR1 | PDGFRB | PDGFRbeta | PGFRB_HUMAN | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor 1 | Platelet-derived growth factor receptor beta | Platelet-derived growth factor receptor beta (PDGFR-beta) | Platelet-derived growth factor receptor beta (PDGFRB) | Platelet-derived growth factor receptor beta (PDGFRbeta) | VHL/PDGFRB |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 123922.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P09619 |
|---|
| Residue: | 1106 |
|---|
| Sequence: | MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPV
VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFV
PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFS
GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN
EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH
QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS
SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL
ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV
TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA
LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL
VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP
HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL
PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP
SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV
KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG
GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER
LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND
YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV
EPEPELEQLPDSGCPAPRAEAEDSFL
|
|
|
|---|
| BDBM531233 |
|---|
| n/a |
|---|
| Name | BDBM531233 |
|---|
| Synonyms: | (Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-oxoethyl)piperazine-1-carbonyl)phenyl)amino)(phenyl)methylene)-5-methyl-2-oxoindoline-6-carboxylate | US11208381, Example 15 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H40N4O7 |
|---|
| Mol. Mass. | 652.7361 |
|---|
| SMILES | COC(=O)c1cc2N(C(C)=O)C(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CC(=O)OC(C)(C)C)CC3)c3ccccc3)c2cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
