Reaction Details |
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Target | Thioredoxin reductase 1, cytoplasmic |
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Ligand | BDBM531217 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition of Recombinant TrxR1 and GR |
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IC50 | 3.16±0 nM |
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Citation | Pelcman, B; Orwar, O; Stafford, W; Andersson, K Sulfinylpyridines and their use in the treatment of cancer US Patent US11208384 Publication Date 12/28/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Thioredoxin reductase 1, cytoplasmic |
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Name: | Thioredoxin reductase 1, cytoplasmic |
Synonyms: | GRIM-12 | GRIM12 | Gene associated with retinoid-IFN-induced mortality 12 protein | KDRF | KM-102-derived reductase-like factor | TR | TRXR1_HUMAN | TXNRD1 | Thioredoxin reductase 1 | Thioredoxin reductase 1 (TrxR) | Thioredoxin reductase TR1 |
Type: | Protein |
Mol. Mass.: | 70761.78 |
Organism: | Homo sapiens (Human) |
Description: | Q16881 |
Residue: | 648 |
Sequence: | MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCG
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BDBM531217 |
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n/a |
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Name | BDBM531217 |
Synonyms: | US11208384, Example 1 |
Type | Small organic molecule |
Emp. Form. | C12H9ClN2O4S |
Mol. Mass. | 312.729 |
SMILES | COc1ccc(c(n1)S(=O)c1ccc(Cl)cc1)[N+]([O-])=O |
Structure |
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