| Reaction Details |
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 | Report a problem with these data |
| Target | CAM kinase, CDPK family TgCDPK1 |
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| Ligand | BDBM50250012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Expression and Purification of Active Kinases |
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| IC50 | 173±n/a nM |
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| Citation |  Rutaganira, F; Shokat, KM; Sibley, LD; Janetka, JW Compositions and methods for treating parasitic diseases US Patent US11208411 Publication Date 12/28/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| CAM kinase, CDPK family TgCDPK1 |
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| Name: | CAM kinase, CDPK family TgCDPK1 |
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| Synonyms: | TgCDPK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57248.42 |
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| Organism: | Toxoplasma gondii (strain ATCC 50861 / VEG) |
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| Description: | n/a |
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| Residue: | 507 |
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| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
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| BDBM50250012 |
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| n/a |
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| Name | BDBM50250012 |
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| Synonyms: | CHEMBL4080552 | US11208411, Compound MLC468 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20F2N6 |
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| Mol. Mass. | 358.3884 |
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| SMILES | Nc1ncnc2n(CC3CCNCC3)nc(Cc3cc(F)cc(F)c3)c12 |
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| Structure | 
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