| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor XI |
|---|
| Ligand | BDBM304228 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Factor XIa Assay |
|---|
| IC50 | 0.100±n/a nM |
|---|
| Citation |  Shen, D; Kuang, R; Kumar, P; Duffy, JL; Zhu, C; Ali, A; Yang, M; Debenham, JS Factor XIa inhibitors US Patent US10143681 Publication Date 12/4/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor XI |
|---|
| Name: | Coagulation factor XI |
|---|
| Synonyms: | Coagulation factor XIa | Coagulation factor XIa heavy chain | Coagulation factor XIa light chain | F11 | FA11_HUMAN | FXI | Factor XIa | Factor XIa (fXIa) | PTA | Plasma thromboplastin antecedent |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70130.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03951 |
|---|
| Residue: | 625 |
|---|
| Sequence: | MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFT
FTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDM
KGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITK
LDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFT
FFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTD
FLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKIL
HGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSI
IGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYD
IALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLV
TNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCA
QRERPGVYTNVVEYVDWILEKTQAV
|
|
|
|---|
| BDBM304228 |
|---|
| n/a |
|---|
| Name | BDBM304228 |
|---|
| Synonyms: | 2-(1-((4-carboxy-3- fluorophenyl)amino)-3- cyclobutyl-1-oxopropan-2- yl)-5-(3-chloro-6- (difluoromethyl)-2- fluorophenyl)pyridine 1- oxide | BDBM304229 | US10143681, Example 119 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H21ClF4N2O4 |
|---|
| Mol. Mass. | 536.903 |
|---|
| SMILES | OC(=O)c1ccc(NC(=O)C(CC2CCC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)F)cc1F |$;;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$| |
|---|
| Structure | 
|
|---|
Search and Browse
