| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 9 |
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| Ligand | BDBM532239 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Recombinant TASK-1 and TASK-3 In Vitro |
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| IC50 | 9.20±n/a nM |
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| Citation |  Delbeck, M; Hahn, M; Müller, T; Lustig, K; Anlahr, J; Collins, K; Nicolai, J; Beck-Broichsitter, M; Albus, U; Gehring, D; Rosenstein, B; Dang, H; Duan, D; Yang, J; Chen, D Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors US Patent US11208422 Publication Date 12/28/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 9 |
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| Name: | Potassium channel subfamily K member 9 |
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| Synonyms: | Acid-sensitive potassium channel protein TASK-3 | KCNK9 | KCNK9_HUMAN | TASK3 | TWIK-related acid-sensitive K(+) channel 3 | Two pore K(+) channel KT3.2 | Two pore potassium channel KT3.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42276.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457494 |
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| Residue: | 374 |
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| Sequence: | MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYR
QLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPL
TLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQ
CEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLN
LVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCT
CYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHS
FTDHQRLMKRRKSV
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| BDBM532239 |
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| n/a |
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| Name | BDBM532239 |
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| Synonyms: | US11208422, Example 80 | US11208422, Example 81 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25ClFN5O |
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| Mol. Mass. | 489.972 |
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| SMILES | Fc1ccccc1C(=O)N1C2CCC1CN(Cc1c(nc3ncccn13)-c1ccc(Cl)cc1)CC2 |
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| Structure | 
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