Reaction Details |
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Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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Ligand | BDBM532280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Vps34 Biochemical Assay |
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IC50 | 12.0±n/a nM |
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Citation | Lindström, J; Forsblom, R; Ginman, T; Rahm, F; Viklund, J Pyridinamine-pyridone and pyrimidinamine- pyridone compounds US Patent US11208423 Publication Date 12/28/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 |
Type: | Enzyme |
Mol. Mass.: | 101551.30 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. |
Residue: | 887 |
Sequence: | MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
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BDBM532280 |
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n/a |
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Name | BDBM532280 |
Synonyms: | 4-[2-[(1-Methylimidazol-4-yl)amino]-4-pyridyl]-6-[2-(trifluoromethyl)phenyl]-1H-pyridin-2-one | US11208423, Example 62 | US11780858, Example 62 |
Type | Small organic molecule |
Emp. Form. | C21H16F3N5O |
Mol. Mass. | 411.3798 |
SMILES | Cn1cnc(Nc2cc(ccn2)-c2cc([nH]c(=O)c2)-c2ccccc2C(F)(F)F)c1 |
Structure |
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