| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Ligand | BDBM470606 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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| IC50 | 0.103±n/a nM |
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| Citation |  Harrington, PE; Ashton, K; Brown, SP; Kaller, MR; Kohn, TJ; Lanman, BA; Li, K; Li, Y; Low, JD; Minatti, AE; Pickrell, AJ; Stec, MM; Taygerly, J Compounds that inhibits MCL-1 protein US Patent US11224601 Publication Date 1/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Name: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 17896.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820[171-327] |
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| Residue: | 157 |
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| Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
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| Component 2 |
| Name: | Bcl-2-like protein 11 [51-76] |
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| Synonyms: | B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 2530.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43521[51-76] |
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| Residue: | 26 |
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| Sequence: | EGDSCPHGSP QGPLAPPASP GPFATR
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| BDBM470606 |
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| n/a |
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| Name | BDBM470606 |
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| Synonyms: | US10821115, Example 10 | US11224601, Example 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H57ClN4O5S |
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| Mol. Mass. | 765.444 |
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| SMILES | CO[C@]1(CN2CCN3CCCC[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:16| |
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| Structure | 
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