Compile Data Set for Download or QSAR

Found 6318 hits with Last Name = 'low' and Initial = 'jd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471418 (US10821115, Example 100433 | US11224601, Example 1...) Show SMILES C[C@H]1C\C=C\[C@](O)(C#CCC2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C40H49ClN2O6S/c1-27-6-3-18-40(45,19-4-7-29-15-20-48-21-16-29)35-12-9-32(35)24-43-25-39(17-5-8-30-22-33(41)11-13-34(30)39)26-49-37-14-10-31(23-36(37)43)38(44)42-50(46,47)28(27)2/h3,10-11,13-14,18,22-23,27-29,32,35,45H,5-9,12,15-17,20-21,24-26H2,1-2H3,(H,42,44)/b18-3+/t27-,28+,32-,35+,39-,40-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0260	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471418 (US10821115, Example 100433 | US11224601, Example 1...) Show SMILES C[C@H]1C\C=C\[C@](O)(C#CCC2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C40H49ClN2O6S/c1-27-6-3-18-40(45,19-4-7-29-15-20-48-21-16-29)35-12-9-32(35)24-43-25-39(17-5-8-30-22-33(41)11-13-34(30)39)26-49-37-14-10-31(23-36(37)43)38(44)42-50(46,47)28(27)2/h3,10-11,13-14,18,22-23,27-29,32,35,45H,5-9,12,15-17,20-21,24-26H2,1-2H3,(H,42,44)/b18-3+/t27-,28+,32-,35+,39-,40-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0260	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471530 (US10821115, Example 100547 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC2=NC(C)(C)C(=O)O2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:4,13| Show InChI InChI=1S/C39H48ClN3O7S/c1-24-8-6-17-39(48-5,20-34-41-37(3,4)36(45)50-34)31-13-10-28(31)21-43-22-38(16-7-9-26-18-29(40)12-14-30(26)38)23-49-33-15-11-27(19-32(33)43)35(44)42-51(46,47)25(24)2/h6,11-12,14-15,17-19,24-25,28,31H,7-10,13,16,20-23H2,1-5H3,(H,42,44)/b17-6+/t24-,25+,28-,31+,38-,39+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM533816 ((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-methox...) Show SMILES CO[C@@]1(CN2CCN(CC2)[C@@H]2CCOC(=O)C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471530 (US10821115, Example 100547 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC2=NC(C)(C)C(=O)O2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:4,13| Show InChI InChI=1S/C39H48ClN3O7S/c1-24-8-6-17-39(48-5,20-34-41-37(3,4)36(45)50-34)31-13-10-28(31)21-43-22-38(16-7-9-26-18-29(40)12-14-30(26)38)23-49-33-15-11-27(19-32(33)43)35(44)42-51(46,47)25(24)2/h6,11-12,14-15,17-19,24-25,28,31H,7-10,13,16,20-23H2,1-5H3,(H,42,44)/b17-6+/t24-,25+,28-,31+,38-,39+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470886 ((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-methox...) Show SMILES CO[C@@]1(CN2CCN(CC2)[C@H]2CCOC(=O)C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI InChI=1S/C43H57ClN4O7S/c1-29-6-4-16-43(53-3,27-46-17-19-47(20-18-46)35-14-21-54-40(49)24-35)37-11-8-33(37)25-48-26-42(15-5-7-31-22-34(44)10-12-36(31)42)28-55-39-13-9-32(23-38(39)48)41(50)45-56(51,52)30(29)2/h4,9-10,12-13,16,22-23,29-30,33,35,37H,5-8,11,14-15,17-21,24-28H2,1-3H3,(H,45,50)/b16-4+/t29-,30+,33-,35-,37+,42-,43+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471007 (US10821115, Example 100020 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(CS(=O)(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C35H46ClN3O7S2/c1-23-7-5-16-35(41,22-47(42,43)38(3)4)30-12-9-27(30)19-39-20-34(15-6-8-25-17-28(36)11-13-29(25)34)21-46-32-14-10-26(18-31(32)39)33(40)37-48(44,45)24(23)2/h5,10-11,13-14,16-18,23-24,27,30,41H,6-9,12,15,19-22H2,1-4H3,(H,37,40)/b16-5+/t23-,24+,27-,30+,34-,35+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471007 (US10821115, Example 100020 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(CS(=O)(=O)N(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C35H46ClN3O7S2/c1-23-7-5-16-35(41,22-47(42,43)38(3)4)30-12-9-27(30)19-39-20-34(15-6-8-25-17-28(36)11-13-29(25)34)21-46-32-14-10-26(18-31(32)39)33(40)37-48(44,45)24(23)2/h5,10-11,13-14,16-18,23-24,27,30,41H,6-9,12,15,19-22H2,1-4H3,(H,37,40)/b16-5+/t23-,24+,27-,30+,34-,35+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471293 (US10821115, Example 100308 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(C#CCCN(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C38H48ClN3O5S/c1-26-9-7-19-38(44,18-5-6-20-41(3)4)33-14-11-30(33)23-42-24-37(17-8-10-28-21-31(39)13-15-32(28)37)25-47-35-16-12-29(22-34(35)42)36(43)40-48(45,46)27(26)2/h7,12-13,15-16,19,21-22,26-27,30,33,44H,6,8-11,14,17,20,23-25H2,1-4H3,(H,40,43)/b19-7+/t26-,27+,30-,33+,37-,38-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0330	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471293 (US10821115, Example 100308 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(C#CCCN(C)C)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C38H48ClN3O5S/c1-26-9-7-19-38(44,18-5-6-20-41(3)4)33-14-11-30(33)23-42-24-37(17-8-10-28-21-31(39)13-15-32(28)37)25-47-35-16-12-29(22-34(35)42)36(43)40-48(45,46)27(26)2/h7,12-13,15-16,19,21-22,26-27,30,33,44H,6,8-11,14,17,20,23-25H2,1-4H3,(H,40,43)/b19-7+/t26-,27+,30-,33+,37-,38-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0330	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470885 (US10821115, Example 270 | US11224601, Example 270) Show SMILES CO[C@@]1(CN2CCN(CC(O)=O)CC2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:15| Show InChI InChI=1S/C40H53ClN4O7S/c1-27-6-4-15-40(51-3,25-44-18-16-43(17-19-44)23-37(46)47)34-11-8-31(34)22-45-24-39(14-5-7-29-20-32(41)10-12-33(29)39)26-52-36-13-9-30(21-35(36)45)38(48)42-53(49,50)28(27)2/h4,9-10,12-13,15,20-21,27-28,31,34H,5-8,11,14,16-19,22-26H2,1-3H3,(H,42,48)(H,46,47)/b15-4+/t27-,28+,31-,34+,39-,40+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470885 (US10821115, Example 270 | US11224601, Example 270) Show SMILES CO[C@@]1(CN2CCN(CC(O)=O)CC2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:15| Show InChI InChI=1S/C40H53ClN4O7S/c1-27-6-4-15-40(51-3,25-44-18-16-43(17-19-44)23-37(46)47)34-11-8-31(34)22-45-24-39(14-5-7-29-20-32(41)10-12-33(29)39)26-52-36-13-9-30(21-35(36)45)38(48)42-53(49,50)28(27)2/h4,9-10,12-13,15,20-21,27-28,31,34H,5-8,11,14,16-19,22-26H2,1-3H3,(H,42,48)(H,46,47)/b15-4+/t27-,28+,31-,34+,39-,40+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471363 (US10821115, Example 100378 | US11224601, Example 1...) Show SMILES COC[C@]1(O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:5| Show InChI InChI=1S/C34H43ClN2O6S/c1-22-6-4-15-34(39,21-42-3)29-11-8-26(29)18-37-19-33(14-5-7-24-16-27(35)10-12-28(24)33)20-43-31-13-9-25(17-30(31)37)32(38)36-44(40,41)23(22)2/h4,9-10,12-13,15-17,22-23,26,29,39H,5-8,11,14,18-21H2,1-3H3,(H,36,38)/b15-4+/t22-,23+,26-,29+,33-,34+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471363 (US10821115, Example 100378 | US11224601, Example 1...) Show SMILES COC[C@]1(O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:5| Show InChI InChI=1S/C34H43ClN2O6S/c1-22-6-4-15-34(39,21-42-3)29-11-8-26(29)18-37-19-33(14-5-7-24-16-27(35)10-12-28(24)33)20-43-31-13-9-25(17-30(31)37)32(38)36-44(40,41)23(22)2/h4,9-10,12-13,15-17,22-23,26,29,39H,5-8,11,14,18-21H2,1-3H3,(H,36,38)/b15-4+/t22-,23+,26-,29+,33-,34+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471004 (US10821115, Example 100017 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(C#CCCN2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C40H50ClN3O6S/c1-28-7-5-17-40(46,16-3-4-18-43-19-21-49-22-20-43)35-12-9-32(35)25-44-26-39(15-6-8-30-23-33(41)11-13-34(30)39)27-50-37-14-10-31(24-36(37)44)38(45)42-51(47,48)29(28)2/h5,10-11,13-14,17,23-24,28-29,32,35,46H,4,6-9,12,15,18-22,25-27H2,1-2H3,(H,42,45)/b17-5+/t28-,29+,32-,35+,39-,40-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0390	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470893 ((3R)-3-(4- (((1S,3'R,6'R,7'S,8'E,11'S, 12'R)-6-ch...) Show SMILES CO[C@@]1(CN2CCN(CC2)[C@H](CCO)CC(O)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI InChI=1S/C43H59ClN4O8S/c1-29-6-4-16-43(55-3,27-46-17-19-47(20-18-46)35(14-21-49)24-40(50)51)37-11-8-33(37)25-48-26-42(15-5-7-31-22-34(44)10-12-36(31)42)28-56-39-13-9-32(23-38(39)48)41(52)45-57(53,54)30(29)2/h4,9-10,12-13,16,22-23,29-30,33,35,37,49H,5-8,11,14-15,17-21,24-28H2,1-3H3,(H,45,52)(H,50,51)/b16-4+/t29-,30+,33-,35+,37+,42-,43+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471004 (US10821115, Example 100017 | US10821115, Example 1...) Show SMILES C[C@H]1C\C=C\[C@@](O)(C#CCCN2CCOCC2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C40H50ClN3O6S/c1-28-7-5-17-40(46,16-3-4-18-43-19-21-49-22-20-43)35-12-9-32(35)25-44-26-39(15-6-8-30-23-33(41)11-13-34(30)39)27-50-37-14-10-31(24-36(37)44)38(45)42-51(47,48)29(28)2/h5,10-11,13-14,17,23-24,28-29,32,35,46H,4,6-9,12,15,18-22,25-27H2,1-2H3,(H,42,45)/b17-5+/t28-,29+,32-,35+,39-,40-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0390	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470893 ((3R)-3-(4- (((1S,3'R,6'R,7'S,8'E,11'S, 12'R)-6-ch...) Show SMILES CO[C@@]1(CN2CCN(CC2)[C@H](CCO)CC(O)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI InChI=1S/C43H59ClN4O8S/c1-29-6-4-16-43(55-3,27-46-17-19-47(20-18-46)35(14-21-49)24-40(50)51)37-11-8-33(37)25-48-26-42(15-5-7-31-22-34(44)10-12-36(31)42)28-56-39-13-9-32(23-38(39)48)41(52)45-57(53,54)30(29)2/h4,9-10,12-13,16,22-23,29-30,33,35,37,49H,5-8,11,14-15,17-21,24-28H2,1-3H3,(H,45,52)(H,50,51)/b16-4+/t29-,30+,33-,35+,37+,42-,43+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0390	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471430 (US10821115, Example 100445 | US11224601, Example 1...) Show SMILES COCCOC[C@@]1(O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:8| Show InChI InChI=1S/C36H47ClN2O7S/c1-24-6-4-15-36(41,23-45-17-16-44-3)31-11-8-28(31)20-39-21-35(14-5-7-26-18-29(37)10-12-30(26)35)22-46-33-13-9-27(19-32(33)39)34(40)38-47(42,43)25(24)2/h4,9-10,12-13,15,18-19,24-25,28,31,41H,5-8,11,14,16-17,20-23H2,1-3H3,(H,38,40)/b15-4+/t24-,25+,28-,31+,35-,36-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471430 (US10821115, Example 100445 | US11224601, Example 1...) Show SMILES COCCOC[C@@]1(O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:8| Show InChI InChI=1S/C36H47ClN2O7S/c1-24-6-4-15-36(41,23-45-17-16-44-3)31-11-8-28(31)20-39-21-35(14-5-7-26-18-29(37)10-12-30(26)35)22-46-33-13-9-27(19-32(33)39)34(40)38-47(42,43)25(24)2/h4,9-10,12-13,15,18-19,24-25,28,31,41H,5-8,11,14,16-17,20-23H2,1-3H3,(H,38,40)/b15-4+/t24-,25+,28-,31+,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471543 (US10821115, Example 100560 | US11224601, Example 1...) Show SMILES CO[C@@]1(Cc2cc(C)ccn2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:12| Show InChI InChI=1S/C40H48ClN3O5S/c1-26-15-18-42-33(19-26)22-40(48-4)17-5-7-27(2)28(3)50(46,47)43-38(45)30-10-14-37-36(21-30)44(23-31-9-12-35(31)40)24-39(25-49-37)16-6-8-29-20-32(41)11-13-34(29)39/h5,10-11,13-15,17-21,27-28,31,35H,6-9,12,16,22-25H2,1-4H3,(H,43,45)/b17-5+/t27-,28+,31-,35+,39-,40+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471543 (US10821115, Example 100560 | US11224601, Example 1...) Show SMILES CO[C@@]1(Cc2cc(C)ccn2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:12| Show InChI InChI=1S/C40H48ClN3O5S/c1-26-15-18-42-33(19-26)22-40(48-4)17-5-7-27(2)28(3)50(46,47)43-38(45)30-10-14-37-36(21-30)44(23-31-9-12-35(31)40)24-39(25-49-37)16-6-8-29-20-32(41)11-13-34(29)39/h5,10-11,13-15,17-21,27-28,31,35H,6-9,12,16,22-25H2,1-4H3,(H,43,45)/b17-5+/t27-,28+,31-,35+,39-,40+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471422 (US10821115, Example 100437 | US10821115, Example 1...) Show SMILES CO[C@@]1(C[C@H](O)C2CC2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:10| Show InChI InChI=1S/C38H49ClN2O6S/c1-24-6-4-17-38(46-3,20-34(42)26-8-9-26)32-13-10-29(32)21-41-22-37(16-5-7-27-18-30(39)12-14-31(27)37)23-47-35-15-11-28(19-33(35)41)36(43)40-48(44,45)25(24)2/h4,11-12,14-15,17-19,24-26,29,32,34,42H,5-10,13,16,20-23H2,1-3H3,(H,40,43)/b17-4+/t24-,25+,29-,32+,34-,37-,38+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0420	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471422 (US10821115, Example 100437 | US10821115, Example 1...) Show SMILES CO[C@@]1(C[C@H](O)C2CC2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:10| Show InChI InChI=1S/C38H49ClN2O6S/c1-24-6-4-17-38(46-3,20-34(42)26-8-9-26)32-13-10-29(32)21-41-22-37(16-5-7-27-18-30(39)12-14-31(27)37)23-47-35-15-11-28(19-33(35)41)36(43)40-48(44,45)25(24)2/h4,11-12,14-15,17-19,24-26,29,32,34,42H,5-10,13,16,20-23H2,1-3H3,(H,40,43)/b17-4+/t24-,25+,29-,32+,34-,37-,38+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0420	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471450 (US10821115, Example 100466 | US11224601, Example 1...) Show SMILES COCCO[C@@]1(C)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:7| Show InChI InChI=1S/C36H47ClN2O6S/c1-24-7-5-15-35(3,45-18-17-43-4)30-12-9-28(30)21-39-22-36(16-6-8-26-19-29(37)11-13-31(26)36)23-44-33-14-10-27(20-32(33)39)34(40)38-46(41,42)25(24)2/h5,10-11,13-15,19-20,24-25,28,30H,6-9,12,16-18,21-23H2,1-4H3,(H,38,40)/b15-5+/t24-,25+,28-,30+,35-,36-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0430	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471416 (US10821115, Example 100431 | US11224601, Example 1...) Show SMILES CO[C@@]1(CCN2CC(C)(C2)N(C)C)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:14| Show InChI InChI=1S/C41H57ClN4O5S/c1-28-9-7-18-41(50-6,19-20-45-24-39(3,25-45)44(4)5)35-14-11-32(35)23-46-26-40(17-8-10-30-21-33(42)13-15-34(30)40)27-51-37-16-12-31(22-36(37)46)38(47)43-52(48,49)29(28)2/h7,12-13,15-16,18,21-22,28-29,32,35H,8-11,14,17,19-20,23-27H2,1-6H3,(H,43,47)/b18-7+/t28-,29+,32-,35+,40-,41+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0430	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471450 (US10821115, Example 100466 | US11224601, Example 1...) Show SMILES COCCO[C@@]1(C)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:7| Show InChI InChI=1S/C36H47ClN2O6S/c1-24-7-5-15-35(3,45-18-17-43-4)30-12-9-28(30)21-39-22-36(16-6-8-26-19-29(37)11-13-31(26)36)23-44-33-14-10-27(20-32(33)39)34(40)38-46(41,42)25(24)2/h5,10-11,13-15,19-20,24-25,28,30H,6-9,12,16-18,21-23H2,1-4H3,(H,38,40)/b15-5+/t24-,25+,28-,30+,35-,36-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0430	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471416 (US10821115, Example 100431 | US11224601, Example 1...) Show SMILES CO[C@@]1(CCN2CC(C)(C2)N(C)C)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:14| Show InChI InChI=1S/C41H57ClN4O5S/c1-28-9-7-18-41(50-6,19-20-45-24-39(3,25-45)44(4)5)35-14-11-32(35)23-46-26-40(17-8-10-30-21-33(42)13-15-34(30)40)27-51-37-16-12-31(22-36(37)46)38(47)43-52(48,49)29(28)2/h7,12-13,15-16,18,21-22,28-29,32,35H,8-11,14,17,19-20,23-27H2,1-6H3,(H,43,47)/b18-7+/t28-,29+,32-,35+,40-,41+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0430	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471560 (US10821115, Example 100577 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC(=O)NCc2ncco2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:14| Show InChI InChI=1S/C39H47ClN4O7S/c1-25-6-4-15-39(49-3,20-35(45)42-21-36-41-16-17-50-36)32-11-8-29(32)22-44-23-38(14-5-7-27-18-30(40)10-12-31(27)38)24-51-34-13-9-28(19-33(34)44)37(46)43-52(47,48)26(25)2/h4,9-10,12-13,15-19,25-26,29,32H,5-8,11,14,20-24H2,1-3H3,(H,42,45)(H,43,46)/b15-4+/t25-,26+,29-,32+,38-,39+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0450	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471560 (US10821115, Example 100577 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC(=O)NCc2ncco2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:14| Show InChI InChI=1S/C39H47ClN4O7S/c1-25-6-4-15-39(49-3,20-35(45)42-21-36-41-16-17-50-36)32-11-8-29(32)22-44-23-38(14-5-7-27-18-30(40)10-12-31(27)38)24-51-34-13-9-28(19-33(34)44)37(46)43-52(47,48)26(25)2/h4,9-10,12-13,15-19,25-26,29,32H,5-8,11,14,20-24H2,1-3H3,(H,42,45)(H,43,46)/b15-4+/t25-,26+,29-,32+,38-,39+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0450	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470777 ((1S,3'R,6'R,7'S,8'E,10'S,11'S)- 6-chloro-7'-((9aS)...) Show SMILES C[C@@H]1CS(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@](O)(CN4CCN5CCCC[C@@H]5C4)\C=C\[C@@H]1C)c3c2 |r,t:51| Show InChI InChI=1S/C41H55ClN4O5S/c1-28-14-16-41(48,26-44-18-19-45-17-4-3-7-34(45)23-44)36-11-8-32(36)22-46-25-40(15-5-6-30-20-33(42)10-12-35(30)40)27-51-38-13-9-31(21-37(38)46)39(47)43-52(49,50)24-29(28)2/h9-10,12-14,16,20-21,28-29,32,34,36,48H,3-8,11,15,17-19,22-27H2,1-2H3,(H,43,47)/b16-14+/t28-,29+,32-,34+,36+,40-,41+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0470	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470777 ((1S,3'R,6'R,7'S,8'E,10'S,11'S)- 6-chloro-7'-((9aS)...) Show SMILES C[C@@H]1CS(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@](O)(CN4CCN5CCCC[C@@H]5C4)\C=C\[C@@H]1C)c3c2 |r,t:51| Show InChI InChI=1S/C41H55ClN4O5S/c1-28-14-16-41(48,26-44-18-19-45-17-4-3-7-34(45)23-44)36-11-8-32(36)22-46-25-40(15-5-6-30-20-33(42)10-12-35(30)40)27-51-38-13-9-31(21-37(38)46)39(47)43-52(49,50)24-29(28)2/h9-10,12-14,16,20-21,28-29,32,34,36,48H,3-8,11,15,17-19,22-27H2,1-2H3,(H,43,47)/b16-14+/t28-,29+,32-,34+,36+,40-,41+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0470	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471292 (US10821115, Example 100307 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC(O)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:7| Show InChI InChI=1S/C35H43ClN2O7S/c1-22-6-4-15-35(44-3,18-32(39)40)29-11-8-26(29)19-38-20-34(14-5-7-24-16-27(36)10-12-28(24)34)21-45-31-13-9-25(17-30(31)38)33(41)37-46(42,43)23(22)2/h4,9-10,12-13,15-17,22-23,26,29H,5-8,11,14,18-21H2,1-3H3,(H,37,41)(H,39,40)/b15-4+/t22-,23+,26-,29+,34-,35+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471292 (US10821115, Example 100307 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC(O)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:7| Show InChI InChI=1S/C35H43ClN2O7S/c1-22-6-4-15-35(44-3,18-32(39)40)29-11-8-26(29)19-38-20-34(14-5-7-24-16-27(36)10-12-28(24)34)21-45-31-13-9-25(17-30(31)38)33(41)37-46(42,43)23(22)2/h4,9-10,12-13,15-17,22-23,26,29H,5-8,11,14,18-21H2,1-3H3,(H,37,41)(H,39,40)/b15-4+/t22-,23+,26-,29+,34-,35+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471483 (US10821115, Example 100500 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC2=NCCO2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:4,10| Show InChI InChI=1S/C37H46ClN3O6S/c1-24-6-4-15-37(45-3,20-34-39-16-17-46-34)31-11-8-28(31)21-41-22-36(14-5-7-26-18-29(38)10-12-30(26)36)23-47-33-13-9-27(19-32(33)41)35(42)40-48(43,44)25(24)2/h4,9-10,12-13,15,18-19,24-25,28,31H,5-8,11,14,16-17,20-23H2,1-3H3,(H,40,42)/b15-4+/t24-,25+,28-,31+,36-,37+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471483 (US10821115, Example 100500 | US11224601, Example 1...) Show SMILES CO[C@@]1(CC2=NCCO2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:4,10| Show InChI InChI=1S/C37H46ClN3O6S/c1-24-6-4-15-37(45-3,20-34-39-16-17-46-34)31-11-8-28(31)21-41-22-36(14-5-7-26-18-29(38)10-12-30(26)36)23-47-33-13-9-27(19-32(33)41)35(42)40-48(43,44)25(24)2/h4,9-10,12-13,15,18-19,24-25,28,31H,5-8,11,14,16-17,20-23H2,1-3H3,(H,40,42)/b15-4+/t24-,25+,28-,31+,36-,37+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM543871 ((1S,3'R,6'S,7'S,11'S,12'R)- 7'-(((9aS)-8- acetyloc...) Show SMILES C[C@H]1CCC[C@H](CN2CCN3CCN(C[C@@H]3C2)C(C)=O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PC35KF
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471432 (US10821115, Example 100447 | US11224601, Example 1...) Show SMILES [#6]-[#8][C@@]1([#6]\[#6]=[#6](\[#6])-[#6])\[#6]=[#6]\[#6]-[#6@H](-[#6])-[#6@@H](-[#6])S(=O)(=O)[#7]-[#6](=O)-c2ccc3-[#8]-[#6][C@]4([#6]-[#6]-[#6]-c5cc(Cl)ccc45)[#6]-[#7](-[#6]-[#6@@H]-4-[#6]-[#6]-[#6@@H]1-4)-c3c2 |r,t:8| Show InChI InChI=1S/C38H49ClN2O5S/c1-25(2)16-19-38(45-5)18-6-8-26(3)27(4)47(43,44)40-36(42)29-11-15-35-34(21-29)41(22-30-10-13-33(30)38)23-37(24-46-35)17-7-9-28-20-31(39)12-14-32(28)37/h6,11-12,14-16,18,20-21,26-27,30,33H,7-10,13,17,19,22-24H2,1-5H3,(H,40,42)/b18-6+/t26-,27+,30-,33+,37-,38+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471432 (US10821115, Example 100447 | US11224601, Example 1...) Show SMILES [#6]-[#8][C@@]1([#6]\[#6]=[#6](\[#6])-[#6])\[#6]=[#6]\[#6]-[#6@H](-[#6])-[#6@@H](-[#6])S(=O)(=O)[#7]-[#6](=O)-c2ccc3-[#8]-[#6][C@]4([#6]-[#6]-[#6]-c5cc(Cl)ccc45)[#6]-[#7](-[#6]-[#6@@H]-4-[#6]-[#6]-[#6@@H]1-4)-c3c2 |r,t:8| Show InChI InChI=1S/C38H49ClN2O5S/c1-25(2)16-19-38(45-5)18-6-8-26(3)27(4)47(43,44)40-36(42)29-11-15-35-34(21-29)41(22-30-10-13-33(30)38)23-37(24-46-35)17-7-9-28-20-31(39)12-14-32(28)37/h6,11-12,14-16,18,20-21,26-27,30,33H,7-10,13,17,19,22-24H2,1-5H3,(H,40,42)/b18-6+/t26-,27+,30-,33+,37-,38+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470833 ((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...) Show SMILES CO[C@]1(CN2CCN3CCN(C[C@@H]3C2)C(C)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI InChI=1S/C43H58ClN5O6S/c1-29-7-5-16-43(54-4,27-46-17-18-47-19-20-48(31(3)50)25-36(47)24-46)38-12-9-34(38)23-49-26-42(15-6-8-32-21-35(44)11-13-37(32)42)28-55-40-14-10-33(22-39(40)49)41(51)45-56(52,53)30(29)2/h5,10-11,13-14,16,21-22,29-30,34,36,38H,6-9,12,15,17-20,23-28H2,1-4H3,(H,45,51)/b16-5+/t29-,30+,34-,36-,38+,42-,43-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0510	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470833 ((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 7''-(((9aR)-...) Show SMILES CO[C@]1(CN2CCN3CCN(C[C@@H]3C2)C(C)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI InChI=1S/C43H58ClN5O6S/c1-29-7-5-16-43(54-4,27-46-17-18-47-19-20-48(31(3)50)25-36(47)24-46)38-12-9-34(38)23-49-26-42(15-6-8-32-21-35(44)11-13-37(32)42)28-55-40-14-10-33(22-39(40)49)41(51)45-56(52,53)30(29)2/h5,10-11,13-14,16,21-22,29-30,34,36,38H,6-9,12,15,17-20,23-28H2,1-4H3,(H,45,51)/b16-5+/t29-,30+,34-,36-,38+,42-,43-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0510	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470895 ((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 7'-((4-(1-acetyl-3...) Show SMILES CO[C@@]1(CN2CCN(CC2)C2CN(C2)C(C)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI InChI=1S/C43H58ClN5O6S/c1-29-7-5-16-43(54-4,27-46-17-19-47(20-18-46)36-24-48(25-36)31(3)50)38-12-9-34(38)23-49-26-42(15-6-8-32-21-35(44)11-13-37(32)42)28-55-40-14-10-33(22-39(40)49)41(51)45-56(52,53)30(29)2/h5,10-11,13-14,16,21-22,29-30,34,36,38H,6-9,12,15,17-20,23-28H2,1-4H3,(H,45,51)/b16-5+/t29-,30+,34-,38+,42-,43+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470831 ((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 6-chloro-7''...) Show SMILES CO[C@]1(CN2CCN3CCS(=O)(=O)C[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:18| Show InChI InChI=1S/C41H55ClN4O7S2/c1-28-6-4-15-41(52-3,26-44-16-17-45-18-19-54(48,49)24-34(45)23-44)36-11-8-32(36)22-46-25-40(14-5-7-30-20-33(42)10-12-35(30)40)27-53-38-13-9-31(21-37(38)46)39(47)43-55(50,51)29(28)2/h4,9-10,12-13,15,20-21,28-29,32,34,36H,5-8,11,14,16-19,22-27H2,1-3H3,(H,43,47)/b15-4+/t28-,29+,32-,34-,36+,40-,41-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470831 ((1S,3''R,6''R,7''R,8''E,11''S,12''R)- 6-chloro-7''...) Show SMILES CO[C@]1(CN2CCN3CCS(=O)(=O)C[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:18| Show InChI InChI=1S/C41H55ClN4O7S2/c1-28-6-4-15-41(52-3,26-44-16-17-45-18-19-54(48,49)24-34(45)23-44)36-11-8-32(36)22-46-25-40(14-5-7-30-20-33(42)10-12-35(30)40)27-53-38-13-9-31(21-37(38)46)39(47)43-55(50,51)29(28)2/h4,9-10,12-13,15,20-21,28-29,32,34,36H,5-8,11,14,16-19,22-27H2,1-3H3,(H,43,47)/b15-4+/t28-,29+,32-,34-,36+,40-,41-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470958 ((1S,3'R,6'R,7'R,8'E,11'S,12'R)- 6-chloro-7'-(((3R,...) Show SMILES CCN1[C@@H](C)CN(C[C@@]2(OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)C[C@H]1C |r,t:11| Show InChI InChI=1S/C42H59ClN4O5S/c1-7-47-29(3)22-45(23-30(47)4)26-42(51-6)19-8-10-28(2)31(5)53(49,50)44-40(48)33-13-17-39-38(21-33)46(24-34-12-15-37(34)42)25-41(27-52-39)18-9-11-32-20-35(43)14-16-36(32)41/h8,13-14,16-17,19-21,28-31,34,37H,7,9-12,15,18,22-27H2,1-6H3,(H,44,48)/b19-8+/t28-,29-,30+,31+,34-,37+,41-,42-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470895 ((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 7'-((4-(1-acetyl-3...) Show SMILES CO[C@@]1(CN2CCN(CC2)C2CN(C2)C(C)=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:19| Show InChI InChI=1S/C43H58ClN5O6S/c1-29-7-5-16-43(54-4,27-46-17-19-47(20-18-46)36-24-48(25-36)31(3)50)38-12-9-34(38)23-49-26-42(15-6-8-32-21-35(44)11-13-37(32)42)28-55-40-14-10-33(22-39(40)49)41(51)45-56(52,53)30(29)2/h5,10-11,13-14,16,21-22,29-30,34,36,38H,6-9,12,15,17-20,23-28H2,1-4H3,(H,45,51)/b16-5+/t29-,30+,34-,38+,42-,43+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470958 ((1S,3'R,6'R,7'R,8'E,11'S,12'R)- 6-chloro-7'-(((3R,...) Show SMILES CCN1[C@@H](C)CN(C[C@@]2(OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)C[C@H]1C |r,t:11| Show InChI InChI=1S/C42H59ClN4O5S/c1-7-47-29(3)22-45(23-30(47)4)26-42(51-6)19-8-10-28(2)31(5)53(49,50)44-40(48)33-13-17-39-38(21-33)46(24-34-12-15-37(34)42)25-41(27-52-39)18-9-11-32-20-35(43)14-16-36(32)41/h8,13-14,16-17,19-21,28-31,34,37H,7,9-12,15,18,22-27H2,1-6H3,(H,44,48)/b19-8+/t28-,29-,30+,31+,34-,37+,41-,42-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470604 ((1 S,3′R,6′R,7′R,8′E, 11&#...) Show SMILES CO[C@]1(CN2CCN(C(C)C)[C@H](C)C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:15| Show InChI InChI=1S/C42H59ClN4O5S/c1-28(2)47-20-19-45(23-30(47)4)26-42(51-6)18-7-9-29(3)31(5)53(49,50)44-40(48)33-12-16-39-38(22-33)46(24-34-11-14-37(34)42)25-41(27-52-39)17-8-10-32-21-35(43)13-15-36(32)41/h7,12-13,15-16,18,21-22,28-31,34,37H,8-11,14,17,19-20,23-27H2,1-6H3,(H,44,48)/b18-7+/t29-,30+,31+,34-,37+,41-,42-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0530	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471515 (US10821115, Example 100532 | US11224601, Example 1...) Show SMILES C[C@H]1C\C=C\[C@](O)(Cc2cc(C)ccn2)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3| Show InChI InChI=1S/C39H46ClN3O5S/c1-25-14-17-41-32(18-25)21-39(45)16-4-6-26(2)27(3)49(46,47)42-37(44)29-9-13-36-35(20-29)43(22-30-8-11-34(30)39)23-38(24-48-36)15-5-7-28-19-31(40)10-12-33(28)38/h4,9-10,12-14,16-20,26-27,30,34,45H,5-8,11,15,21-24H2,1-3H3,(H,42,44)/b16-4+/t26-,27+,30-,34+,38-,39-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0530	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				US Patent US10821115 (2020) BindingDB Entry DOI: 10.7270/Q23T9MB5
					More data for this Ligand-Target Pair
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM470604 ((1 S,3′R,6′R,7′R,8′E, 11&#...) Show SMILES CO[C@]1(CN2CCN(C(C)C)[C@H](C)C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:15| Show InChI InChI=1S/C42H59ClN4O5S/c1-28(2)47-20-19-45(23-30(47)4)26-42(51-6)18-7-9-29(3)31(5)53(49,50)44-40(48)33-12-16-39-38(22-33)46(24-34-11-14-37(34)42)25-41(27-52-39)17-8-10-32-21-35(43)13-15-36(32)41/h7,12-13,15-16,18,21-22,28-31,34,37H,8-11,14,17,19-20,23-27H2,1-6H3,(H,44,48)/b18-7+/t29-,30+,31+,34-,37+,41-,42-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0530	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair

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