| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
|---|
| Ligand | BDBM471430 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
|---|
| IC50 | 0.040±n/a nM |
|---|
| Citation |  Harrington, PE; Ashton, K; Brown, SP; Kaller, MR; Kohn, TJ; Lanman, BA; Li, K; Li, Y; Low, JD; Minatti, AE; Pickrell, AJ; Stec, MM; Taygerly, J Compounds that inhibit Mcl-1 protein US Patent US10821115 Publication Date 11/3/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
|---|
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
|---|
| Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 17896.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07820[171-327] |
|---|
| Residue: | 157 |
|---|
| Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
|
|
|
|---|
| BDBM471430 |
|---|
| n/a |
|---|
| Name | BDBM471430 |
|---|
| Synonyms: | US10821115, Example 100445 | US11224601, Example 100445 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H47ClN2O7S |
|---|
| Mol. Mass. | 687.286 |
|---|
| SMILES | COCCOC[C@@]1(O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:8| |
|---|
| Structure | 
|
|---|
Search and Browse
