| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Ligand | BDBM470777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay |
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| IC50 | 0.047±n/a nM |
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| Citation |  Harrington, PE; Ashton, K; Brown, SP; Kaller, MR; Kohn, TJ; Lanman, BA; Li, K; Li, Y; Low, JD; Minatti, AE; Pickrell, AJ; Stec, MM; Taygerly, J Compounds that inhibits MCL-1 protein US Patent US11224601 Publication Date 1/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Name: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 17896.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820[171-327] |
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| Residue: | 157 |
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| Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
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| Component 2 |
| Name: | Bcl-2-like protein 11 [51-76] |
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| Synonyms: | B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 2530.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43521[51-76] |
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| Residue: | 26 |
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| Sequence: | EGDSCPHGSP QGPLAPPASP GPFATR
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| BDBM470777 |
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| n/a |
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| Name | BDBM470777 |
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| Synonyms: | (1S,3'R,6'R,7'S,8'E,10'S,11'S)- 6-chloro-7'-((9aS)- hexahydropyrazino[2,1- c][1,4]oxazin-8(1H)-ylmethyl)- 7'-hydroxy-10',11'-dimethyl- 3,4-dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide | US10821115, Example 164 | US11224601, Example 164 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H55ClN4O5S |
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| Mol. Mass. | 751.417 |
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| SMILES | C[C@@H]1CS(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@](O)(CN4CCN5CCCC[C@@H]5C4)\C=C\[C@@H]1C)c3c2 |r,t:51| |
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| Structure | 
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