Reaction Details |
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Target | E3 ubiquitin-protein ligase Mdm2 |
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Ligand | BDBM535770 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay (ELISA) |
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IC50 | 0.600±n/a nM |
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Citation | Chessari, G; Lyons, JF Combination of isoindolinone derivatives with SGI-110 US Patent US11236047 Publication Date 2/1/2022 |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase Mdm2 |
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Name: | E3 ubiquitin-protein ligase Mdm2 |
Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
Type: | Oncoprotein |
Mol. Mass.: | 55196.54 |
Organism: | Homo sapiens (Human) |
Description: | Q00987 |
Residue: | 491 |
Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM535770 |
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n/a |
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Name | BDBM535770 |
Synonyms: | 2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy-1-(1-methyl-1H- imidazol-4-yl)propyl]-1-[(trans-3- hydroxycyclopentyl)oxy]-3-oxo-2,3- dihydro-1H-isoindol-2- yl]methyl}pyrimidine-5-carbonitrile | US11236047, Example 461 | US11236047, Example 479 |
Type | Small organic molecule |
Emp. Form. | C32H30ClFN6O4 |
Mol. Mass. | 617.07 |
SMILES | CCC(O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ncc(cn3)C#N)[C@](OC3CCC(O)C3)(c2c(F)c1)c1ccc(Cl)cc1 |r| |
Structure |
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