Ki Summary

Reaction Details

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Target

E3 ubiquitin-protein ligase Mdm2

Ligand

BDBM535783

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay (ELISA)

IC50

0.480±n/a nM

Citation

Chessari, G; Lyons, JF Combination of isoindolinone derivatives with SGI-110 US Patent US11236047 Publication Date 2/1/2022

More Info.:

Get all data from this article, Assay Method

E3 ubiquitin-protein ligase Mdm2

Name:

E3 ubiquitin-protein ligase Mdm2

Synonyms:

Type:

Oncoprotein

Mol. Mass.:

55196.54

Organism:

Homo sapiens (Human)

Description:

Q00987

Residue:

491

Sequence:

MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP

BDBM535783

n/a

Name

BDBM535783

Synonyms:

2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-{1-hydroxy-1-[trans-4- hydroxycyclohexyl]propyl}-1-[(2R)-2- hydroxypropoxy]-3-oxo-2,3-dihydro- 1H-isoindol-2-yl]methyl}pyrimidine-5- carbonitrile | US11236047, Example 512

Type

Small organic molecule

Emp. Form.

C32H34ClFN4O5

Mol. Mass.

609.088

SMILES

CCC(O)([C@H]1CC[C@H](O)CC1)c1cc2C(=O)N(Cc3ncc(cn3)C#N)[C@](OC[C@@H](C)O)(c2c(F)c1)c1ccc(Cl)cc1 |r,wU:4.3,26.28,29.32,wD:7.7,(-5.52,-2.86,;-3.98,-2.86,;-3.21,-1.53,;-2.44,-2.86,;-4.55,-.76,;-5.88,-1.53,;-7.21,-.76,;-7.21,.78,;-8.55,1.55,;-5.88,1.55,;-4.55,.78,;-1.88,-.76,;-.55,-1.53,;.79,-.76,;2.25,-1.23,;2.73,-2.7,;3.16,.01,;4.7,.01,;5.47,-1.32,;4.7,-2.65,;5.47,-3.99,;7.04,-4.04,;7.78,-2.65,;7.01,-1.32,;7.81,-5.37,;8.58,-6.7,;2.25,1.26,;1.48,2.59,;1.88,4.08,;.79,5.17,;-.7,4.77,;1.19,6.66,;.79,.78,;-.55,1.55,;-.55,3.09,;-1.88,.78,;3.59,2.03,;4.92,1.26,;6.25,2.03,;6.25,3.57,;7.59,4.34,;4.92,4.34,;3.59,3.57,)|

Structure