| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 14 |
|---|
| Ligand | BDBM536589 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | USP14 Inhibition Assay |
|---|
| IC50 | 550±n/a nM |
|---|
| Citation |  Cullen, M; Hauck, S; Geng, B; Foley, M; Bastos, CM; Munoz, B; Haeberlein, M; Tait, B Proteasome activity enhancing compounds US Patent US11242361 Publication Date 2/8/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin carboxyl-terminal hydrolase 14 |
|---|
| Name: | Ubiquitin carboxyl-terminal hydrolase 14 |
|---|
| Synonyms: | Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56058.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_103728 |
|---|
| Residue: | 494 |
|---|
| Sequence: | MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN
IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV
QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH
MAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKK
SLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK
QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCT
PELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDL
QAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLY
GPRRVEIMEEESEQ
|
|
|
|---|
| BDBM536589 |
|---|
| n/a |
|---|
| Name | BDBM536589 |
|---|
| Synonyms: | US11242361, Compound 196 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27N5O2 |
|---|
| Mol. Mass. | 429.5142 |
|---|
| SMILES | CN(C(C)=O)c1ccc2n(c(C)c(C(=O)CN3CCCCC3)c2n1)-c1ccc(cc1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
