| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Ligand | BDBM539891 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FLIPR Assay for hTRPV4 Expressed in BHK Cells |
|---|
| IC50 | 5±n/a nM |
|---|
| Citation |  Brnardic, EJ; Brooks, CA; Lawhorn, BG; Li, P; Matthews, JM; McAtee, JJ; Pero, JE; Sender, MR; Terrell, LR; Behm, DJ TRPV4 antagonists US Patent US11260049 Publication Date 3/1/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily V member 4 |
|---|
| Name: | Transient receptor potential cation channel subfamily V member 4 |
|---|
| Synonyms: | TRPV4 | TRPV4_HUMAN | Transient receptor potential cation channel subfamily V member 4 (TRPV4) | VRL2 | VROAC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98290.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBA0 |
|---|
| Residue: | 871 |
|---|
| Sequence: | MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
|
|
|
|---|
| BDBM539891 |
|---|
| n/a |
|---|
| Name | BDBM539891 |
|---|
| Synonyms: | 4-(((3S,4R)-1- ((4-fluoro-2- (trifluoromethyl) phenyl)sulfonyl)- 4-hydroxy-4- (hydroxymethyl) pyrrolidin-3- yl)sulfonyl)benzonitrile | US11260049, Ex. 29 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H16F4N2O6S2 |
|---|
| Mol. Mass. | 508.464 |
|---|
| SMILES | OC[C@]1(O)CN(C[C@@H]1S(=O)(=O)c1ccc(cc1)C#N)S(=O)(=O)c1ccc(F)cc1C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
