| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM543214 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Inhibition Assay |
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| IC50 | 0.000±n/a nM |
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| Citation |  Bair, KW; Baumeister, TR; Buckmelter, AJ; Clodfelter, KH; Han, B; Lin, J; Reynolds, DJ; Smith, CC; Wang, Z; Zheng, X; Yuen, P Compounds and compositions for the inhibition of NAMPT US Patent US11279687 Publication Date 3/22/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM543214 |
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| n/a |
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| Name | BDBM543214 |
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| Synonyms: | 3-(4-{[3-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)-1-(pyridin-3- ylmethyl)urea | US11279687, Compound 223 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18FN5O3S |
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| Mol. Mass. | 451.473 |
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| SMILES | Fc1cc(ccc1-n1cccn1)S(=O)(=O)c1ccc(NC(=O)NCc2cccnc2)cc1 |
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| Structure | 
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