| Reaction Details |
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 | Report a problem with these data |
| Target | Atypical chemokine receptor 3 |
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| Ligand | BDBM549988 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| IC50 | 0.300±n/a nM |
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| Citation |  Aissaoui, H; Guerry, P; Lehembre, F; Pothier, J; Pouzol, L; Richard-Bildstein, S; Yuan, S Piperidine CXCR7 receptor modulators US Patent US11306078 Publication Date 4/19/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Atypical chemokine receptor 3 |
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| Name: | Atypical chemokine receptor 3 |
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| Synonyms: | ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41498.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25106 |
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| Residue: | 362 |
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| Sequence: | MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMI
ANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVT
HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDT
YYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAIS
ASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVT
QCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQS
TK
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| BDBM549988 |
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| n/a |
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| Name | BDBM549988 |
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| Synonyms: | (3S,4S)-1-Cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3- carbonyl]-amino}-piperidine-3-carboxylic acid (1-methyl-1-pyridin-2-yl- ethyl)-amide | US11306078, Example 4.033 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31F2N5O3 |
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| Mol. Mass. | 523.5742 |
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| SMILES | CC(C)(NC(=O)[C@H]1CN(CC2CC2)CC[C@@H]1NC(=O)c1cc(on1)-c1ccc(F)cc1F)c1ccccn1 |
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| Structure | 
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