Reaction Details | |||
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Target | Non-receptor tyrosine-protein kinase TYK2 | ||
Ligand | BDBM305831 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | JAK Caliper Enzyme Assay at 1 mM ATP | ||
IC50 | 7.00±n/a nM | ||
Citation | Brown, MF; Dermenci, A; Fensome, A; Gerstenberger, BS; Hayward, MM; Owen, DR; Wright, SW; Xing, LH; Yang, X Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives US Patent US10144738 Publication Date 12/4/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Non-receptor tyrosine-protein kinase TYK2 | |||
Name: | Non-receptor tyrosine-protein kinase TYK2 | ||
Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 | ||
Type: | Protein | ||
Mol. Mass.: | 133666.03 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P29597 | ||
Residue: | 1187 | ||
Sequence: |
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BDBM305831 | |||
n/a | |||
Name | BDBM305831 | ||
Synonyms: | 2-((1r,3s)-1-(4-(6-(3-Amino-1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)-3-methoxycyclobutyl)acetonitrile | US10144738, Example 30 | US10822341, Example 30 | US11472809, Example 30 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H19N9O | ||
Mol. Mass. | 389.4139 | ||
SMILES | CO[C@H]1C[C@@](CC#N)(C1)n1cc(cn1)-c1nc(cn2nccc12)-c1cc(N)[nH]n1 |r,wU:4.9,wD:2.1,(-.8,7.41,;-2.13,6.64,;-2.13,5.1,;-3.22,4.01,;-2.13,2.93,;-2.9,1.59,;-4.44,1.59,;-5.98,1.59,;-1.04,4.01,;-1.36,1.59,;-1.84,.13,;-.59,-.78,;.65,.13,;.18,1.59,;-.59,-2.32,;.74,-3.09,;.74,-4.63,;-.59,-5.4,;-1.93,-4.63,;-3.39,-5.1,;-4.3,-3.86,;-3.39,-2.61,;-1.93,-3.09,;2.07,-5.4,;3.54,-4.92,;4.44,-6.17,;5.98,-6.17,;3.54,-7.41,;2.07,-6.94,)| | ||
Structure |