| Reaction Details |
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 | Report a problem with these data |
| Target | Polymerase basic protein 2 |
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| Ligand | BDBM552314 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EN PA FRET Inhibition Assay |
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| IC50 | 2.40±n/a nM |
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| Citation |  Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent US11312727 Publication Date 4/26/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Polymerase basic protein 2 |
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| Name: | Polymerase basic protein 2 |
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| Synonyms: | B4URF7_I33A0 | PB2 | RNA-directed RNA polymerase subunit P3 |
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| Type: | Protein |
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| Mol. Mass.: | 85824.43 |
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| Organism: | Influenza A virus (strain A/WS/1933 H1N1) |
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| Description: | B4URF7 |
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| Residue: | 759 |
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| Sequence: | MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITAD
KRITEMIPERNEQGQTLWSKMNDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKIYKTYFE
KVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSE
SQLTTTKEKKEELQGCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCW
EQMYTPGGEARNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGVRMVNILRQ
NPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGY
EEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNF
VNRANQRLNPMHQLLRHFQKDAKVLFQNWGIESIDNVMGMIGILPDMTPSTEMSMRGVRI
SKMGVDEYSSAEKIVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEIN
GPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAVRGQYSGFVRTLF
QQMRDVLGTFDTAQIIKLLPFAAAPPKQSGMQFSSLTINVRGSGMRILVRGNSPVFNYNK
TTKRLTVLGKDAGPLTEDPDEGTAGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGE
KANVLIGQGDVVLVMKRKRNSSILTDSQTATKRIRMAIN
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| BDBM552314 |
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| n/a |
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| Name | BDBM552314 |
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| Synonyms: | (13*S,21a*R,Z)-13-ethyl-24,25-difluoro-16-hydroxy-6,10,13,21a-tetrahydro-7,8-(epiprop[1]en[1]yl[3]ylidene)-14,21-methanobenzo[6,7]thiepino[4,5-c]pyrido[1,2-f][1]oxa[5,6,9]triazacyclotridecine-15,17-dione (Compound 126AA) | US11312727, Compound 126BB |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23F2N3O4S |
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| Mol. Mass. | 523.551 |
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| SMILES | CC[C@@H]1\C=C/COc2cc(F)c(F)c3CSc4ccccc4[C@@H](N4CN1C(=O)c1c(O)c(=O)ccn41)c23 |r,c:3| |
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| Structure | 
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