| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional polynucleotide phosphatase/kinase |
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| Ligand | BDBM553806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Steady-State Fluorescence Assay |
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| Kd | 550±n/a nM |
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| Citation |  Hall, D; Weinfeld, M; Bernard, S; Verdelet, T; Morgan, T; Lamontagne, V; Shire, Z; Lavasanifar, A Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase US Patent US11325905 Publication Date 5/10/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional polynucleotide phosphatase/kinase |
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| Name: | Bifunctional polynucleotide phosphatase/kinase |
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| Synonyms: | DNA 5'-kinase/3'-phosphatase | PNKP | PNKP_HUMAN | Polynucleotide kinase-3'-phosphatase |
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| Type: | Protein |
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| Mol. Mass.: | 57085.26 |
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| Organism: | Human |
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| Description: | Q96T60 |
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| Residue: | 521 |
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| Sequence: | MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPP
GTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTR
SGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAEEFKAKVEAVV
EKLGVPFQVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPG
RKKKDFSCADRLFALNLGLPFATPEEFFLKWPAAGFELPAFDPRTVSRSGPLCLPESRAL
LSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVA
IDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMY
GYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG
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| BDBM553806 |
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| n/a |
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| Name | BDBM553806 |
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| Synonyms: | US11325905, Compound A5B4C3 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N5O5 |
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| Mol. Mass. | 513.5445 |
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| SMILES | CN(C)c1ccc(cc1)[C@H](O)C1C=CC2[C@H](N1Nc1ccc(cc1)N(=O)=O)C(=O)N(C2=O)c1ccccc1 |r,c:13| |
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| Structure | 
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