Reaction Details |
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Target | Bifunctional polynucleotide phosphatase/kinase |
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Ligand | BDBM553919 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Steady-State Fluorescence Assay |
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IC50 | 22000±n/a nM |
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Citation | Hall, D; Weinfeld, M; Bernard, S; Verdelet, T; Morgan, T; Lamontagne, V; Shire, Z; Lavasanifar, A Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase US Patent US11325905 Publication Date 5/10/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional polynucleotide phosphatase/kinase |
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Name: | Bifunctional polynucleotide phosphatase/kinase |
Synonyms: | DNA 5'-kinase/3'-phosphatase | PNKP | PNKP_HUMAN | Polynucleotide kinase-3'-phosphatase |
Type: | Protein |
Mol. Mass.: | 57085.26 |
Organism: | Human |
Description: | Q96T60 |
Residue: | 521 |
Sequence: | MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADPETR
TVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGLHPLTLRWEETRTPESQPDTPP
GTPLVSQDEKRDAELPKKRMRKSNPGWENLEKLLVFTAAGVKPQGKVAGFDLDGTLITTR
SGKVFPTGPSDWRILYPEIPRKLRELEAEGYKLVIFTNQMSIGRGKLPAEEFKAKVEAVV
EKLGVPFQVLVATHAGLYRKPVTGMWDHLQEQANDGTPISIGDSIFVGDAAGRPANWAPG
RKKKDFSCADRLFALNLGLPFATPEEFFLKWPAAGFELPAFDPRTVSRSGPLCLPESRAL
LSASPEVVVAVGFPGAGKSTFLKKHLVSAGYVHVNRDTLGSWQRCVTTCETALKQGKRVA
IDNTNPDAASRARYVQCARAAGVPCRCFLFTATLEQARHNNRFREMTDSSHIPVSDMVMY
GYRKQFEAPTLAEGFSAILEIPFRLWVEPRLGRLYCQFSEG
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BDBM553919 |
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n/a |
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Name | BDBM553919 |
Synonyms: | US11325905, Compound A44B4C60 |
Type | Small organic molecule |
Emp. Form. | C26H22BrN5O5 |
Mol. Mass. | 564.387 |
SMILES | OC(C1C=CC2[C@H](N1Nc1ccc(cc1)N(=O)=O)C(=O)N(Cc1ccccn1)C2=O)c1ccc(Br)cc1 |r,c:3| |
Structure |
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