| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP6 |
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| Ligand | BDBM553954 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Anisotropy Binding Assay |
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| IC50 | 59000±n/a nM |
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| Citation |  Johannes, JW; Hande, SM; Degorce, SL; Packer, MJ Chemical compounds US Patent US11325906 Publication Date 5/10/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP6 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP6 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 17 | ARTD17 | PARP-6 | PARP6 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71130.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107589 |
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| Residue: | 630 |
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| Sequence: | MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIRE
YGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSN
KEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPI
PKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQH
VGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSM
LKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPS
VVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQW
IISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENW
HSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYN
RMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYED
GQVGDANINTQDPKIQKEIMRVIGTQVYTN
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| BDBM553954 |
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| n/a |
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| Name | BDBM553954 |
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| Synonyms: | US11325906, Example 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20F4N6O2 |
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| Mol. Mass. | 464.4161 |
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| SMILES | CNC(=O)c1ccc(N2CCN(Cc3ccc4nc(c(=O)[nH]c4c3)C(F)(F)F)CC2)c(F)n1 |
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| Structure | 
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