| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 6 |
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| Ligand | BDBM383299 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | <0.020±n/a nM |
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| Citation |  Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent US11376260 Publication Date 7/5/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 6 |
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| Name: | Mitogen-activated protein kinase 6 |
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| Synonyms: | ERK3 | MAPK6 | MK06_HUMAN | PRKM6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82643.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774367 |
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| Residue: | 721 |
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| Sequence: | MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK
HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE
QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP
HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ
MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFS
PMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC
QFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS
TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK
EQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQ
HEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSG
GEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEG
FLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHL
N
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| BDBM383299 |
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| n/a |
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| Name | BDBM383299 |
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| Synonyms: | 4-(9-(4-fluorobenzyl)-8,9- dihydro-7H-6-oxa-1,2,2a1- triazabenzo[cd]azulen-4-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine | US10278975, Compound I-58 S | US11376260, Example I-58S |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21FN8O |
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| Mol. Mass. | 456.4749 |
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| SMILES | Cn1nccc1Nc1nccc(n1)-c1cc2OCC[C@H](Cc3ccc(F)cc3)c3nnc(c1)n23 |r| |
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| Structure | 
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