| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM559897 |
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| Substrate/Competitor | n/a |
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| IC50 | 22.0±n/a nM |
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| Citation |  Holson, E; Wagner, FF; Haggarty, SJ; Zhang, Y; Lundh, M; Wagner, B; Lewis, MC; Petryshen, TL Inhibitors of histone deacetylase US Patent US11377423 Publication Date 7/5/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM559897 |
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| n/a |
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| Name | BDBM559897 |
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| Synonyms: | US11377423, Cmpd 3A |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N4O2 |
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| Mol. Mass. | 372.4198 |
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| SMILES | Nc1ccccc1NC(=O)c1ccc(CNC(=O)\C=C\c2cccnc2)cc1 |
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| Structure | 
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