Reaction Details |
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Target | Arginase-1 |
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Ligand | BDBM290417 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition of Arginase |
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IC50 | 125±n/a nM |
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Citation | Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent US11389464 Publication Date 7/19/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Arginase-1 |
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Name: | Arginase-1 |
Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
Type: | PROTEIN |
Mol. Mass.: | 34737.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_978893 |
Residue: | 322 |
Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
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BDBM290417 |
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n/a |
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Name | BDBM290417 |
Synonyms: | (3R,4S)-3-amino-4-(3-boronopropyl)-1-(1,2,3,4- tetrahydroisoquinoline-3-carbonyl)pyrrolidine-3-carboxylic acid | US10098902, Example 53 | US10603330, Example 53 | US11389464, Example 53 |
Type | Small organic molecule |
Emp. Form. | C18H26BN3O5 |
Mol. Mass. | 375.227 |
SMILES | N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccccc2CN1)C(O)=O |r| |
Structure |
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