| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Ligand | BDBM563125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LpxC Binding Assay |
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| IC50 | 30±n/a nM |
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| Citation |  Teng, M; Nammalwar, B; Li, X; Perez, C; Yule, I; Faulkner, A; Atton, H; Parkes, A; Convers-Reignier, S; Southey, M; Puerta, DT Antibacterial compounds US Patent US11407740 Publication Date 8/9/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
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| Type: | Enzyme |
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| Mol. Mass.: | 33952.00 |
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| Organism: | Escherichia coli |
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| Description: | P0A725 |
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| Residue: | 305 |
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| Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
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| BDBM563125 |
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| n/a |
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| Name | BDBM563125 |
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| Synonyms: | US11407740, Compound 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33FN4O3 |
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| Mol. Mass. | 504.5957 |
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| SMILES | C[C@@H](CF)NCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1 |r| |
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| Structure | 
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