Reaction Details |
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Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Ligand | BDBM563256 |
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Substrate/Competitor | n/a |
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Meas. Tech. | LpxC Binding Assay |
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IC50 | 30±n/a nM |
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Citation | Teng, M; Nammalwar, B; Li, X; Perez, C; Yule, I; Faulkner, A; Atton, H; Parkes, A; Convers-Reignier, S; Southey, M; Puerta, DT Antibacterial compounds US Patent US11407740 Publication Date 8/9/2022 |
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More Info.: | Get all data from this article, Assay Method |
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UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
Type: | Enzyme |
Mol. Mass.: | 33952.00 |
Organism: | Escherichia coli |
Description: | P0A725 |
Residue: | 305 |
Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
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BDBM563256 |
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n/a |
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Name | BDBM563256 |
Synonyms: | 6-(3-(((S)-1-fluoropropan-2-yl)amino)-2-(4-((4-((3-methoxyazetidin-1-yl)methyl)phenyl)ethynyl)phenyl)propyl)-5-hydroxypyrimidin-4(3H)-one | US11407740, Compound 68 |
Type | Small organic molecule |
Emp. Form. | C29H33FN4O3 |
Mol. Mass. | 504.5957 |
SMILES | COC1CN(Cc2ccc(cc2)C#Cc2ccc(cc2)C(CN[C@@H](C)CF)Cc2nc[nH]c(=O)c2O)C1 |r| |
Structure |
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