| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM567769 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Bcl-2/Bcl-X TR-FRET Assay |
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| IC50 | 0.021±n/a nM |
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| Citation |  Guo, Y; Xue, H; Wang, Z; Sun, H Bcl-2 inhibitors US Patent US11420968 Publication Date 8/23/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM567769 |
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| n/a |
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| Name | BDBM567769 |
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| Synonyms: | US11420968, Example F130 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H58N8O7S |
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| Mol. Mass. | 903.099 |
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| SMILES | CCN1CCN(C2CC3(C2)CCN(CC3)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)C(C1)c1ccccc1C1CC1 |
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| Structure | 
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