| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM572872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay and NMN Detection |
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| EC50 | <100±n/a nM |
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| Citation |  Gardell, S; Pinkerton, AB; Sergienko, E; Sessions, H Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof US Patent US11452717 Publication Date 9/27/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM572872 |
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| n/a |
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| Name | BDBM572872 |
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| Synonyms: | C-(3-Chloro-phenyl)-N-{4-[3-(1H-pyrazol-4-ylmethyl)-ureido]-phenyl}-methanesulfonamide | US11452717, Compound TableB-4.15 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClN5O3S |
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| Mol. Mass. | 419.885 |
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| SMILES | Clc1cccc(CS(=O)(=O)Nc2ccc(NC(=O)NCc3cn[nH]c3)cc2)c1 |
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| Structure | 
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