Ki Summary

Reaction Details

Report a problem with these data

Target

Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI

Ligand

BDBM8778

Substrate/Competitor

BDBM8737

Meas. Tech.

Enzyme Inhibition Assay

Temperature

303.15±n/a K

IC50

180±n/a nM

Comments

extracted

Citation

Seefeld, MA; Miller, WH; Newlander, KA; Burgess, WJ; Payne, DJ; Rittenhouse, SF; Moore, TD; DeWolf, WE; Keller, PM; Qiu, X; Janson, CA; Vaidya, K; Fosberry, AP; Smyth, MG; Jaworski, DD; Slater-Radosti, C; Huffman, WF Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents. Bioorg Med Chem Lett11:2241-4 (2001) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI

Name:

Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI

Synonyms:

Type:

Enzyme

Mol. Mass.:

27989.00

Organism:

Staphylococcus aureus

Description:

Q6GI75

Residue:

256

Sequence:

MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK

BDBM8778

BDBM8737

Name

BDBM8778

Synonyms:

1,2,3,4-tetrahydro pyrido[3,4-b]indole 22 | 4-({2-[(4-chlorophenyl)carbonyl]-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-9-yl}methyl)phenol

Type

Small organic molecule

Emp. Form.

C25H21ClN2O2

Mol. Mass.

416.899

SMILES

Oc1ccc(Cn2c3CN(CCc3c3ccccc23)C(=O)c2ccc(Cl)cc2)cc1

Structure