Reaction Details |
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Target | Polymerase acidic protein |
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Ligand | BDBM474341 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Endonuclease Inhibition Assay |
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IC50 | 70.0±n/a nM |
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Citation | Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent US11453677 Publication Date 9/27/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Polymerase acidic protein |
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Name: | Polymerase acidic protein |
Synonyms: | PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2 |
Type: | Protein |
Mol. Mass.: | 82806.72 |
Organism: | n/a |
Description: | P31343 |
Residue: | 716 |
Sequence: | MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGES
IVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEI
GVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQ
EMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNG
CIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNM
KKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDS
IWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDF
QLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKY
CVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSA
ESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
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BDBM474341 |
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n/a |
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Name | BDBM474341 |
Synonyms: | 6-(bis(3-fluorophenyl)methyl)-11-hydroxy- 5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-10- one | US10858366, Example 2 | US11453677, Example 2 |
Type | Small organic molecule |
Emp. Form. | C22H16F2N4O2 |
Mol. Mass. | 406.3848 |
SMILES | Oc1c2-c3nccn3CC(C(c3cccc(F)c3)c3cccc(F)c3)n2ncc1=O |
Structure |
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