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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 | ||
| Ligand | BDBM574931 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ZH2 biochemical assay (IC50) | ||
| IC50 | 0.5±n/a nM | ||
| Citation |  Brenneman, JB; Côté, A; Gehling, VS; Khanna, A; Levell, JR; Moine, L Modulators of methyl modifying enzymes, compositions and uses thereof US Patent US11459315 Publication Date 10/4/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 | |||
| Name: | Histone-lysine N-methyltransferase EZH2 | ||
| Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85367.84 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910 | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM574931 | |||
| n/a | |||
| Name | BDBM574931 | ||
| Synonyms: | 2-methyl-N-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-((R)-1-(4-(2-oxopyrrolidin-1-yl)cyclohexyl)ethyl)-1H-indole-3-carboxamide | US11459315, Example 72 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H38N4O3S | ||
| Mol. Mass. | 534.713 | ||
| SMILES | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCC(CC2)N2CCCC2=O)c2ccccc12 |wU:18.19,(-.49,6.26,;1.02,6.58,;2.05,5.44,;3.56,5.76,;4.59,4.61,;6.09,4.94,;4.11,3.15,;2.6,2.83,;2.13,1.37,;1.57,3.97,;.07,3.65,;-.41,2.19,;-1.92,1.87,;-2.95,3.01,;-2.39,.4,;-1.49,-.84,;.05,-.84,;-2.39,-2.09,;-1.92,-3.55,;-3,-4.64,;-.43,-3.95,;.66,-2.86,;2.15,-3.26,;2.55,-4.75,;1.46,-5.84,;-.03,-5.44,;4.03,-5.15,;4.59,-6.58,;6.12,-6.5,;6.52,-5.02,;5.23,-4.18,;5.23,-2.64,;-3.86,-1.61,;-5.19,-2.38,;-6.52,-1.61,;-6.52,-.07,;-5.19,.7,;-3.86,-.07,)| | ||
| Structure | 
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