Reaction Details | |||
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Report a problem with these data | |||
Target | Tyrosine-protein kinase Mer | ||
Ligand | BDBM308227 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Activity Assay | ||
IC50 | 1.000±n/a nM | ||
Citation | Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity US Patent US9649309 Publication Date 5/16/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Mer | |||
Name: | Tyrosine-protein kinase Mer | ||
Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
Type: | PROTEIN | ||
Mol. Mass.: | 110234.77 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1498723 | ||
Residue: | 999 | ||
Sequence: |
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BDBM308227 | |||
n/a | |||
Name | BDBM308227 | ||
Synonyms: | US9649309, Compound UNC4104A | ||
Type | Small organic molecule | ||
Emp. Form. | C26H41N7O | ||
Mol. Mass. | 467.65 | ||
SMILES | CCCCNc1ncc(c(NC2CCC(O)CC2)n1)-c1ccc(CN2CC[C@H](C2)N(C)C)cn1 |r,wD:27.31,(-10.34,-3.85,;-9.01,-3.08,;-7.67,-3.85,;-6.34,-3.08,;-5.01,-3.85,;-3.67,-3.08,;-2.34,-3.85,;-1.01,-3.08,;-1.01,-1.54,;-2.34,-.77,;-2.34,.77,;-3.67,1.54,;-3.67,3.08,;-5.01,3.85,;-6.34,3.08,;-7.67,3.85,;-6.34,1.54,;-5.01,.77,;-3.67,-1.54,;.33,-.77,;1.66,-1.54,;2.99,-.77,;2.99,.77,;4.33,1.54,;5.66,.77,;5.66,-.77,;7.13,-1.25,;8.03,,;7.13,1.25,;9.57,,;10.34,1.33,;10.34,-1.33,;1.66,1.54,;.33,.77,)| | ||
Structure |