Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM308305 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Activity Assay | ||
| IC50 | 2.30±n/a nM | ||
| Citation |  Wang, X; Zhang, W; Frye, S Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity US Patent US9649309 Publication Date 5/16/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM308305 | |||
| n/a | |||
| Name | BDBM308305 | ||
| Synonyms: | US9649309, Compound UNC4223A | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H34N6OS | ||
| Mol. Mass. | 430.61 | ||
| SMILES | CCCCNc1ncc(-c2ncc(CN3CCCC3)s2)c(NC2CC[C@H](O)CC2)n1 |r,wD:25.27,(-8.41,-3.85,;-7.07,-3.08,;-5.74,-3.85,;-4.41,-3.08,;-3.07,-3.85,;-1.74,-3.08,;-.4,-3.85,;.93,-3.08,;.93,-1.54,;2.26,-.77,;2.26,.77,;3.73,1.25,;4.63,,;6.17,,;6.94,-1.33,;8.41,-1.81,;8.41,-3.35,;6.94,-3.83,;6.04,-2.58,;3.73,-1.25,;-.4,-.77,;-.4,.77,;-1.74,1.54,;-3.07,.77,;-4.41,1.54,;-4.41,3.08,;-5.74,3.85,;-3.07,3.85,;-1.74,3.08,;-1.74,-1.54,)| | ||
| Structure | 
| ||