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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Non-receptor tyrosine-protein kinase TYK2 | ||
| Ligand | BDBM305812 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | JAK Caliper Enzyme Assay at 1 mM ATP | ||
| IC50 | 8.00±n/a nM | ||
| Citation |  Brown, MF; Dermenci, A; Fensome, A; Gerstenberger, BS; Hayward, MM; Owen, DR; Wright, SW; Xing, LH; Yang, X Pyrazolo[1,5-a]pyrazin-4-yl derivatives US Patent US11472809 Publication Date 10/18/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Non-receptor tyrosine-protein kinase TYK2 | |||
| Name: | Non-receptor tyrosine-protein kinase TYK2 | ||
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133666.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29597 | ||
| Residue: | 1187 | ||
| Sequence: |
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| BDBM305812 | |||
| n/a | |||
| Name | BDBM305812 | ||
| Synonyms: | 2,2′-((1s,3s)-1-(4-(6-(1-Methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1,3-diyl)diacetonitrile (cis isomer) | US10144738, Example 11 | US10822341, Example 11 | US11472809, Example 11 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H19N9 | ||
| Mol. Mass. | 397.4359 | ||
| SMILES | Cn1cc(cn1)-c1cn2nccc2c(n1)-c1cnn(c1)[C@]1(CC#N)C[C@H](CC#N)C1 |r,wD:20.23,25.29,(7.49,-1.96,;6.87,-.55,;5.36,-.23,;5.2,1.3,;6.6,1.93,;7.64,.78,;3.86,2.07,;2.53,1.3,;1.2,2.07,;-.27,1.6,;-1.17,2.84,;-.27,4.09,;1.2,3.61,;2.53,4.38,;3.86,3.61,;2.53,5.92,;1.28,6.83,;1.76,8.29,;3.3,8.29,;3.78,6.83,;4.21,9.54,;5.45,8.63,;5.29,7.1,;5.13,5.57,;2.96,10.44,;3.86,11.69,;3.62,13.21,;2.19,13.76,;.75,14.31,;5.11,10.78,)| | ||
| Structure | 
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