| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-glutamine gamma-glutamyltransferase 6 |
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| Ligand | BDBM577483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Transamidation Assay for Determining Inhibitor Selectivity |
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| IC50 | 17.0±n/a nM |
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| Citation |  Hils, M; Pasternack, R; Büchold, C Inhibitors of blood coagulation factor XIII US Patent US11472838 Publication Date 10/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-glutamine gamma-glutamyltransferase 6 |
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| Name: | Protein-glutamine gamma-glutamyltransferase 6 |
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| Synonyms: | Protein-glutamine gamma-glutamyltransferase 6 | TG6 | TGM3L | TGM3L_HUMAN | TGM6 | TGY | TGase Y | TGase-3-like | TGase-6 | Transglutaminase Y | Transglutaminase-3-like | Transglutaminase-6 | Transglutaminase-6 (TG6) |
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| Type: | Protein |
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| Mol. Mass.: | 79319.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 706 |
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| Sequence: | MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMET
GPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSS
HRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYG
QFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQG
KYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNS
AHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQ
EESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKI
GRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRC
LWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTR
KPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEK
DITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTL
EPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK
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| BDBM577483 |
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| n/a |
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| Name | BDBM577483 |
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| Synonyms: | US11472838, Compound 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H59N7O11 |
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| Mol. Mass. | 837.9582 |
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| SMILES | COC(=O)\C=C\CC[C@H](NC(=O)c1ccncc1C(O)=O)C(=O)N[C@H](C(=O)N1CC(=O)C[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O)C(C)(C)C |r| |
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| Structure | 
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