| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor XIII A chain |
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| Ligand | BDBM577485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Isopeptidase Assay for Estimating Inhibitor Potency |
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| IC50 | 16.0±n/a nM |
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| Citation |  Hils, M; Pasternack, R; Büchold, C Inhibitors of blood coagulation factor XIII US Patent US11472838 Publication Date 10/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor XIII A chain |
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| Name: | Coagulation factor XIII A chain |
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| Synonyms: | Coagulation factor XIII | F13A | F13A1 | F13A_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83261.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1475048 |
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| Residue: | 732 |
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| Sequence: | MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
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| BDBM577485 |
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| n/a |
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| Name | BDBM577485 |
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| Synonyms: | US11472838, Compound 2a/b |
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| Type | Small organic molecule |
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| Emp. Form. | C43H57N7O13 |
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| Mol. Mass. | 879.9518 |
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| SMILES | COC(=O)\C=C\CC[C@H](NC(=O)c1cc(ccc1C(O)=O)[N+]([O-])=O)C(=O)N[C@@H](CC1CC1)C(=O)N1CC(=O)C[C@H]1C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](C1CCCCC1)C(N)=O |r| |
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| Structure | 
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