| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [1-535] |
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| Ligand | BDBM578434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Z-lyte assay |
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| IC50 | 258±n/a nM |
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| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R; Zhang, J Inhibitors of Rho associated coiled-coil containing protein kinase US Patent US11479533 Publication Date 10/25/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rho-associated protein kinase 1 [1-535] |
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| Name: | Rho-associated protein kinase 1 [1-535] |
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| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62220.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-535 |
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| Residue: | 535 |
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| Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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| BDBM578434 |
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| n/a |
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| Name | BDBM578434 |
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| Synonyms: | (S)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethylamino)ethyl)amino)-2-(3-methoxyphenyl)acetamide | US11479533, Example 60 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O2 |
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| Mol. Mass. | 393.4821 |
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| SMILES | COc1cccc(c1)[C@H](NCCN(C)C)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 |r| |
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| Structure | 
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