| Reaction Details |
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 | Report a problem with these data |
| Target | hek293 luciferase |
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| Ligand | BDBM578561 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HEK293 luciferase |
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| EC50 | 2.00±n/a nM |
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| Citation |  Bartholomeus, J; Bürli, R; Jarvis, R; Johnstone, S; Ostenfeld, T; Terstiege, I; Travagli, M; Turcotte, S Small molecule modulators of the BTB domain of Keap1 US Patent US11479539 Publication Date 10/25/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| hek293 luciferase |
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| Name: | Gag-Pol polyprotein [588-1147,M628L,D654N,M771V,L797W,T802Y] |
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| Synonyms: | HIV RT (41L/67N/210W/215Y/184V) | POL_HV1H2 | gag-pol |
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| Type: | n/a |
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| Mol. Mass.: | 64571.45 |
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| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) |
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| Description: | P04585[588-1147,M628L,D654N,M771V,L797W,T802Y] |
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| Residue: | 560 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGLYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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| BDBM578561 |
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| n/a |
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| Name | BDBM578561 |
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| Synonyms: | 3-[5-fluoro-3-(1- phenylpyrazol-4- yl)-2-pyridyl]-3- methoxy-5,5- dimethyl-6-oxo- cyclohexene-1- carbonitrile (Enantiomer A) | US11479539, Compound 179 | US11479539, Compound 81 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21FN4O2 |
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| Mol. Mass. | 416.4475 |
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| SMILES | COC1(CC(C)(C)C(=O)C(=C1)C#N)c1ncc(F)cc1-c1cnn(c1)-c1ccccc1 |c:9| |
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| Structure | 
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